Long-term behavioral sensitization to apomorphine is independent of conditioning and increases conditioned pecking, but not preference, in pigeons
Long-term behavioral sensitization to apomorphine is independent of conditioning and increases conditioned pecking, but not preference, in pigeons
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对阿朴吗啡的长期行为敏感性与条件反射无关，并且会增加鸽子的条件啄食，但不会增加偏好
DOI：
10.1016/j.bbr.2017.08.037
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发表时间：
2018
影响因子：
2.7
通讯作者：
Güntürkün
中科院分区：
文献类型：
--
作者：
Anselme;Tabrik;Güntürkün
当让啮齿动物在可变选项和恒定选项之间自由选择时，它们可能更喜欢可变性。在反复使用多巴胺激动剂后，这种偏好有时甚至会增加。本研究首次研究了在系统给药多巴胺激动剂阿朴吗啡(Apo)的情况下，鸟类对可变性的偏好。实验一测试了鸽子在可变延迟上的无毒偏好和选择恒定时间的倾向。他们似乎更喜欢并决定更快地尝试最优的延迟选项。实验2评估了重复注射载脂蛋白对延迟偏好的影响，并与之前在相同个体中进行的对照测试进行了比较。APO治疗可能在不同的实验阶段减少了恒定选项的点击数，但未能诱导出对可变选项的偏好。在试验3中，为了避免处理中的不均质性，使用了两组鸽子(Apo致敏和生理盐水)。他们必须在50%的概率选项和5%的S延迟选项之间做出选择。条件啄食和选择倾向在Apo致敏的鸽子中较高，但在每组中，鸽子对这两种选择都表现出淡漠。这项实验还表明，对载脂蛋白的长期行为敏感化可以独立于条件作用过程发生。这些结果表明，Apo敏化可以提高条件性线索的吸引力，而不影响对可变延迟和概率强化时间表的偏好的发展。
When rodents are given a free choice between a variable option and a constant option, they may prefer variability. This preference is even sometimes increased following repeated administration of a dopamine agonist. The present study was the first to examine preference for variability under the systemic administration of a dopamine agonist, apomorphine (Apo), in birds. Experiment 1 tested the drug-free preference and the propensity to choose of pigeons for a constant over a variable delay. It appeared that they preferred and decided more quickly to peck at the optimal delay option. Experiment 2 assessed the effects of a repeated injection of Apo on delay preference, in comparison with previous control tests within the same individuals. Apo treatment might have decreased the number of pecks at the constant option across the different experimental phases, but failed to induce a preference for the variable option. In Experiment 3, two groups of pigeons (Apo-sensitized and saline) were used in order to avoid inhomogeneity in treatments. They had to choose between a 50% probability option and a 5-s delay option. Conditioned pecking and the propensity to choose were higher in the Apo-sensitized pigeons, but, in each group, the pigeons showed indifference between the two options. This experiment also showed that long-term behavioral sensitization to Apo can occur independently of a conditioning process. These results suggest that Apo sensitization can enhance the attractiveness of conditioned cues, while having no effect on the development of a preference for variable-delay and probabilistic schedules of reinforcement.
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