The Prognostic and Predictive Significance of circRNA CDR1as in Tumor Progression.
The Prognostic and Predictive Significance of circRNA CDR1as in Tumor Progression.
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DOI：
10.3389/fonc.2020.549982
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发表时间：
2020
影响因子：
4.7
通讯作者：
Zhaoji P
中科院分区：
文献类型：
--
作者：
Jian F;Yangyang R;Wei X;Jiadan X;Na L;Peng Y;Maohong B;Guoping N;Zhaoji P
小脑变性相关蛋白1反义（CDR 1as）是circRNA家族的重要成员，也称为cirs-7。它在体内的主要功能是充当mir-7海绵。大量研究表明，CDR 1as与多种疾病尤其是癌症密切相关。我们的分析表明，人类癌症中CDR 1as的表达与总体生存率低显著相关（风险比[HR] = 2.50，95%置信区间[CI] = 2.06-3.04; p < 0.00001），并且高CDR 1as表达与肿瘤淋巴结转移阶段相关（比值比[OR] = 2.13，95%CI = 1.63-2.78; p < 0.00001）和远处转移（OR = 3.50，95%CI = 1.90-6.64; p < 0.00001）。此外，结果揭示了CDR 1as在消化系统肿瘤中的预后意义。（HR = 1.69，95% CI = 2.14-2.71; p < 0.001），结直肠癌（HR = 1.34，95%CI = 1.96-2.85; p < 0.001）和非小细胞肺癌（HR = 2.40，95%CI = 3.42-4.83; p = 0.008）。本文详细总结了CDR 1as在各种癌症过程中的作用和调控机制，并探讨了其作为癌症预防和预后生物标志物的潜力。
Cerebellar degeneration-related protein 1 antisense (CDR1as) is an important member of the circRNAs family, also known as cirs-7. Its main function in vivo is to act as a mir-7 sponge. Accumulated studies show that CDR1as is closely related to various diseases, especially cancer. Our analysis show that CDR1as expression in human cancer is significantly associated with poor overall survival (hazard ratio [HR] = 2.50, 95% confidence interval [CI] = 2.06–3.04; p < 0.00001) and that high CDR1as expression is associated with the tumor node metastasis stage (odds ratio [OR] = 2.13, 95% CI = 1.63–2.78; p < 0.00001), and distant metastasis (OR = 3.50, 95% CI = 1.90–6.64; p < 0.00001). Furthermore, the results reveal the prognostic significance of CDR1as in neoplasms of the digestive system (HR = 1.69, 95% CI = 2.14–2.71; p < 0.001), colorectal cancer (HR = 1.34, 95% CI = 1.96–2.85; p < 0.001), and non-small cell lung cancer (HR = 2.40, 95% CI = 3.42–4.83; p = 0.008). In this study, we summarize in detail the latest research findings and demonstrate the function and regulatory mechanism of CDR1as in various cancer processes, and its potential as a biomarker for cancer prevention and prognosis.
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影响因子：
4.5
作者：
Burd CE;Jeck WR;Liu Y;Sanoff HK;Wang Z;Sharpless NE
通讯作者：
Sharpless NE
圆形RNA电路的多态性和表达模式有助于肝细胞癌的癌变。
影响因子：
--
作者：
Guo W;Zhang J;Zhang D;Cao S;Li G;Zhang S;Wang Z;Wen P;Yang H;Shi X;Pan J;Ye H
通讯作者：
Ye H
影响因子：
4.6
作者：
Bachmayr-Heyda A;Reiner AT;Auer K;Sukhbaatar N;Aust S;Bachleitner-Hofmann T;Mesteri I;Grunt TW;Zeillinger R;Pils D
通讯作者：
Pils D
影响因子：
4.6
作者：
Barrett, Steven P.;Salzman, Julia
通讯作者：
Salzman, Julia
影响因子：
2.9
作者：
Bolha L;Ravnik-Glavač M;Glavač D
通讯作者：
Glavač D