Associations of circulating saturated long-chain fatty acids with risk of mild cognitive impairment and Alzheimer's disease in the Alzheimer's Disease Neuroimaging Initiative (ADNI) cohort.
Associations of circulating saturated long-chain fatty acids with risk of mild cognitive impairment and Alzheimer's disease in the Alzheimer's Disease Neuroimaging Initiative (ADNI) cohort.
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DOI：
10.1016/j.ebiom.2023.104818
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发表时间：
2023-11
期刊：
影响因子：
11.1
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中科院分区：
文献类型：
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没有研究检查外周饱和长链脂肪酸（LCFA）和从轻度认知障碍（MCI）到阿尔茨海默病（AD）的转换之间的关联。本研究旨在检查循环饱和LCFA是否与认知正常（CN）参与者的MCI事件风险和阿尔茨海默病神经影像学倡议（ADNI）队列中MCI进展的AD事件风险相关。我们对来自美国和加拿大63个研究中心的55-90岁老年人的数据进行了分析。我们检查了循环饱和LCFA（即，C14：0、C16：0、C18：0、C20：0）和CN受试者发生MCI的风险，以及从MCI进展为AD的风险。入组ADNI-1的829名参与者有血浆饱和LCFA数据，其中618名无AD参与者被纳入我们的分析（226名认知正常，392名MCI; 60.2%为男性）。使用考克斯比例风险模型解释至事件时间/删失，主要分析随访期为48个月。除C20：0外，饱和LCFA与基线MCI参与者的AD风险增加相关（完全校正模型中的风险比（HR）= 1.3至2.2，P = 0.0005至0.003）。未观察到C20：0与MCI参与者的AD风险相关。在认知正常的参与者中，未观察到饱和LCFA与MCI风险之间的关联。饱和LCFA与从MCI进展为AD的风险增加相关。这一发现有可能促进MCI患者中AD的精确预防。.
No study has examined the associations between peripheral saturated long-chain fatty acids (LCFAs) and conversion from mild cognitive impairment (MCI) to Alzheimer’s disease (AD). This study aimed to examine whether circulating saturated LCFAs are associated with both risks of incident MCI from cognitively normal (CN) participants and incident AD progressed from MCI in the Alzheimer’s Disease Neuroimaging Initiative (ADNI) cohort. We conducted analysis of data from older adults aged 55–90 years who were recruited at 63 sites across the USA and Canada. We examined associations between circulating saturated LCFAs (i.e., C14:0, C16:0, C18:0, C20:0) and risk for incident MCI in CN participants, and incident AD progressed from MCI. 829 participants who were enrolled in ADNI-1 had data on plasma saturated LCFAs, of which 618 AD-free participants were included in our analysis (226 with normal cognition and 392 with MCI; 60.2% were men). Cox proportional-hazards models were used to account for time-to-event/censor with a 48-month follow-up period for the primary analysis. Other than C20:0, saturated LCFAs were associated with an increased risk for AD among participants with MCI at baseline (Hazard ratios (HRs) = 1.3 to 2.2, P = 0.0005 to 0.003 in fully-adjusted models). No association of C20:0 with risk of AD among participants with MCI was observed. No associations were observed between saturated LCFAs and risk for MCI among participants with normal cognition. Saturated LCFAs are associated with increased risk of progressing from MCI to AD. This finding holds the potential to facilitate precision prevention of AD among patients with MCI. .
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