Artemisia pollen allergy in China: Component-resolved diagnosis reveals allergic asthma patients have significant multiple allergen sensitization.
Artemisia pollen allergy in China: Component-resolved diagnosis reveals allergic asthma patients have significant multiple allergen sensitization.
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中国的蒿花粉过敏：成分解析诊断显示过敏性哮喘患者存在显着的多种过敏原致敏
作者：
Gao Z;Fu WY;Sun Y;Gao B;Wang HY;Liu M;Luo FM;Zhou X;Jin J;Zhao L;Wu S;Liu Y;Wu L;Wang X;Tang NB;Guo BH;Feng Y;Zhou JY;Gadermaier G;Ferreira F;Versteeg SA;van Ree R
蒿属花粉过敏是中国北方哮喘的主要原因。对蒿属过敏原成分的IgE反应与临床表型之间可能的关联尚未得到评价。本研究旨在建立中国三个地区四种蒿属变应原的致敏模式及其与人口学特征和临床表型的可能关联。本文对240例蒿属花粉过敏患者进行了检查，其中北方山西178例，山东30例，云南32例。诊断为过敏性哮喘、鼻炎、结膜炎和湿疹症状。通过ImmunoCAP用艾蒿花粉提取物和天然组分nArt v 1、nArt ar 2、nArt v 3和nArt an 7测试所有患者的血清。西南地区蒿属过敏患者的致敏率和4种成分的IgE水平均显著低于北方地区。Art v 1和Art an 7是最常见的过敏原（分别为84%和87%），其次是Art v 3（66%）和Art ar 2（48%）。来自中国北方的患者（50%）比来自中国西南部的患者（3%）更有可能发生过敏性哮喘，对两种以上过敏原致敏会增加过敏性哮喘的风险，其中对三种主要过敏原Art v 1、Art v 3和Art an 7的共致敏作用较为突出。中国蒿属花粉过敏患者的成分分辨诊断有助于评估艾蒿相关过敏性哮喘的潜在风险。
Artemisia pollen allergy is a major cause of asthma in Northern China. Possible associations between IgE responses to Artemisia allergen components and clinical phenotypes have not yet been evaluated. This study was to establish sensitization patterns of four Artemisia allergens and possible associations with demographic characteristics and clinical phenotypes in three areas of China. Two hundred and forty patients allergic to Artemisia pollen were examined, 178 from Shanxi and 30 from Shandong Provinces in Northern China, and 32 from Yunnan Province in Southwestern China. Allergic asthma, rhinitis, conjunctivitis, and eczema symptoms were diagnosed. All patients’ sera were tested by ImmunoCAP with mugwort pollen extract and the natural components nArt v 1, nArt ar 2, nArt v 3, and nArt an 7. The frequency of sensitization and the IgE levels of the four components in Artemisia allergic patients from Southwestern China were significantly lower than in those from the North. Art v 1 and Art an 7 were the most frequently recognized allergens (84% and 87%, respectively), followed by Art v 3 (66%) and Art ar 2 (48%). Patients from Northern China were more likely to have allergic asthma (50%) than patients from Southwestern China (3%), and being sensitized to more than two allergens increased the risk of allergic asthma, in which co‐sensitization to three major allergens Art v 1, Art v 3, and Art an 7 is prominent. Component‐resolved diagnosis of Chinese Artemisia pollen‐allergic patients helps assess the potential risk of mugwort‐associated allergic asthma.
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影响因子：
12.4
作者：
Wang XY;Ma TT;Wang XY;Zhuang Y;Wang XD;Ning HY;Shi HY;Yu RL;Yan D;Huang HD;Bai YF;Shan GL;Zhang B;Song QK;Zhang YF;Zhang TJ;Jia DZ;Liu XL;Kang ZX;Yan WJ;Yang BT;Bao XZ;Sun SH;Zhang FF;Yu WH;Bai CL;Wei T;Yang T;Ma TQ;Wu XB;Liu JG;Du H;Zhang L;Yan Y;Wang DY
通讯作者：
Wang DY
影响因子：
12.4
作者：
Li, J.;Sun, B.;Zhong, N.
通讯作者：
Zhong, N.
影响因子：
12.4
作者：
Fu, W.;Gao, Z.;van Ree, R.
通讯作者：
van Ree, R.
影响因子：
12.4
作者：
Gadermaier, G.;Wopfner, N.;Hawranek, T.
通讯作者：
Hawranek, T.
影响因子：
12.4
作者：
Smith, M.;Jaeger, S.;van Ree, R.
通讯作者：
van Ree, R.