Transcranial alternating current stimulation affects the BOLD signal in a frequency and task-dependent manner.
Transcranial alternating current stimulation affects the BOLD signal in a frequency and task-dependent manner.
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DOI：
10.1002/hbm.23016
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发表时间：
2016-01
影响因子：
4.8
通讯作者：
Wilke, Melanie
中科院分区：
文献类型：
--
作者：
Cabral-Calderin, Yuranny;Weinrich, Christiane Anne;Schmidt-Samoa, Carsten;Poland, Eva;Dechent, Peter;Baehr, Mathias;Wilke, Melanie
经颅交流电刺激（tACS）已成为一种有前途的工具，用于操纵正在进行的脑振荡。虽然以前的研究表明tACS对不同认知功能的频率特异性影响，但其对神经活动的影响仍然知之甚少。在这里，我们问如何tACS调制区域fMRI血氧水平依赖（BOLD）信号的频率，电流强度和任务条件的函数。TACS应用于健康人类受试者的后皮质，而BOLD信号在休息或任务条件下（视觉感知，被动视频观看和运动任务）进行测量。TACS以不同频率（10、16、60和80 Hz）以分块方式应用。在α（10 Hz）和β（16 Hz）频带刺激下观察到tACS对BOLD活性的最强影响，而在γ范围内tACS的影响相当温和。具体来说，我们发现16 Hz的tACS诱导了额顶叶区域的BOLD活动增加。总的来说，tACS效应随频率和任务的变化而变化，主要见于任务未激活的区域。此外，调制区域预测电流密度建模研究。总而言之，我们的结果表明，tACS不一定在电极下方的区域发挥最强的作用，并且由于大脑区域对给定频率的敏感性不同，tACS可能会实现区域特异性。《脑地图》37：94-121，2016年。© 2015作者。人类大脑图谱由Wiley Periodicals，Inc出版
Transcranial alternating current stimulation (tACS) has emerged as a promising tool for manipulating ongoing brain oscillations. While previous studies demonstrated frequency‐specific effects of tACS on diverse cognitive functions, its effect on neural activity remains poorly understood. Here we asked how tACS modulates regional fMRI blood oxygenation level dependent (BOLD) signal as a function of frequency, current strength, and task condition. TACS was applied over the posterior cortex of healthy human subjects while the BOLD signal was measured during rest or task conditions (visual perception, passive video viewing and motor task). TACS was applied in a blockwise manner at different frequencies (10, 16, 60 and 80 Hz). The strongest tACS effects on BOLD activity were observed with stimulation at alpha (10 Hz) and beta (16 Hz) frequency bands, while effects of tACS at the gamma range were rather modest. Specifically, we found that tACS at 16 Hz induced BOLD activity increase in fronto‐parietal areas. Overall, tACS effects varied as a function of frequency and task, and were predominantly seen in regions that were not activated by the task. Also, the modulated regions were poorly predicted by current density modeling studies. Taken together, our results suggest that tACS does not necessarily exert its strongest effects in regions below the electrodes and that region specificity might be achieved with tACS due to varying susceptibility of brain regions to entrain to a given frequency. Hum Brain Mapp 37:94–121, 2016. © 2015 The Authors. Human Brain Mapping Published by Wiley Periodicals, Inc
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影响因子：
5.7
作者：
Gonçalves, SI;de Munck, JC;da Silva, FHL
通讯作者：
da Silva, FHL
早期视觉皮层中额叶信号的自下而上的门控。
DOI：
10.1126/science.1153276
发表时间：
2008-07-18
期刊：
Science (New York, N.Y.)
影响因子：
--
作者：
Ekstrom LB;Roelfsema PR;Arsenault JT;Bonmassar G;Vanduffel W
通讯作者：
Vanduffel W
影响因子：
9.2
作者：
Joundi, Raed A.;Jenkinson, Ned;Brittain, John-Stuart;Aziz, Tipu Z.;Brown, Peter
通讯作者：
Brown, Peter
影响因子：
5.3
作者：
Feurra, Matteo;Pasqualetti, Patrizio;Rossi, Simone
通讯作者：
Rossi, Simone
影响因子：
3.8
作者：
Feurra M;Paulus W;Walsh V;Kanai R
通讯作者：
Kanai R