Timing of daily calorie loading affects appetite and hunger responses without changes in energy metabolism in healthy subjects with obesity.
Timing of daily calorie loading affects appetite and hunger responses without changes in energy metabolism in healthy subjects with obesity.
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DOI：
10.1016/j.cmet.2022.08.001
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发表时间：
2022-10-04
期刊：
影响因子：
29
通讯作者：
Johnstone, Alexandra M.
中科院分区：
文献类型：
--
作者：
Ruddick-Collins, Leonie C.;Morgan, Peter J.;Fyfe, Claire L.;Filipe, Joao A. N.;Horgan, Graham W.;Westerterp, Klaas R.;Johnston, Jonathan D.;Johnstone, Alexandra M.
人类早晨的卡路里摄入量被认为是改善体重减轻的饮食策略。这也得到了动物研究的支持，表明进食时间可以防止体重增加。然而，进食时间可以促进人类体重减轻的潜在机制尚不清楚。在一项随机交叉试验（NCT 03305237）中，30例肥胖/超重受试者接受了两次为期4周的热量限制但能量相等的减肥饮食，早晨或晚上负荷热量（早餐、午餐和晚餐分别为45%：35%：20%和20%：35%：45%）。我们证明，每日总能量消耗或静息代谢率与热量分配的时间无关，体重减轻也无差异。早上进食的参与者报告饥饿感明显降低。因此，早晨负荷摄入（丰盛的早餐）可能有助于通过更大程度地抑制食欲来遵守减肥方案。比较早晨负荷（ML）与晚上负荷（EL）能量摄入饮食。两种饮食产生相似的体重减轻，在能量代谢方面没有差异。ML能量摄入导致每日主观食欲和饥饿感降低。行为变化（摄入量减少）可能解释ML饮食的减肥益处。研究了每日热量分配对能量平衡、新陈代谢和食欲的影响。无论热量分布如何，体重减轻和能量消耗都是相似的。早晨负荷的卡路里摄入导致更大的食欲抑制，这可能导致在随意进食条件下更大的体重减轻。
Morning loaded calorie intake in humans has been advocated as a dietary strategy to improve weight loss. This is also supported by animal studies suggesting time of eating can prevent weight gain. However, the underlying mechanisms through which timing of eating could promote weight loss in humans are unclear. In a randomized crossover trial (NCT03305237), 30 subjects with obesity/overweight underwent two 4-week calorie-restricted but isoenergetic weight loss diets, with morning loaded or evening loaded calories (45%:35%:20% versus 20%:35%:45% calories at breakfast, lunch, and dinner, respectively). We demonstrate no differences in total daily energy expenditure or resting metabolic rate related to the timing of calorie distribution, and no difference in weight loss. Participants consuming the morning loaded diet reported significantly lower hunger. Thus, morning loaded intake (big breakfast) may assist with compliance to weight loss regime through a greater suppression of appetite. Morning loaded (ML) versus evening loaded (EL) energy intake diets were compared Both diets produced similar weight loss, with no differences in energy metabolism ML energy intake resulted in lower daily subjective appetite and hunger Behavioral changes (reduced intake) likely explain weight loss benefits of ML diets Ruddick-Collins et al. studied the effects of daily calorie distribution on energy balance, metabolism, and appetite. Weight loss and energy expenditure were similar regardless of calorie distribution. Morning loaded calorie intake resulted in greater appetite suppression, which may lead to greater weight loss under ad libitum eating conditions.
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影响因子：
6
作者：
FULLER, NJ;JEBB, SA;ELIA, M
通讯作者：
ELIA, M
影响因子：
4.2
作者：
de Castro, JM
通讯作者：
de Castro, JM
影响因子：
6.3
作者：
Coutinho, Silvia Ribeiro;With, Emilie;Martins, Catia
通讯作者：
Martins, Catia
DOI：
10.3945/ajcn.114.083402
发表时间：
2014-08
期刊：
The American journal of clinical nutrition
影响因子：
--
作者：
Betts JA;Richardson JD;Chowdhury EA;Holman GD;Tsintzas K;Thompson D
通讯作者：
Thompson D
影响因子：
5.9
作者：
Beaulieu, Kristine;Oustric, Pauline;Finlayson, Graham
通讯作者：
Finlayson, Graham