Quantitative light microscopic autoradiographic localization of cholinergic muscarinic receptors in the human brain: Brainstem

Quantitative light microscopic autoradiographic localization of cholinergic muscarinic receptors in the human brain: Brainstem
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人脑中胆碱能毒蕈碱受体的定量光显微放射自显影定位:脑干

DOI:
10.1016/0306-4522(84)90001-0
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发表时间:
1984
期刊:
影响因子:
3.3
通讯作者:
J. Palacios
J. Palacios
中科院分区:
医学3区
文献类型:
--
作者:
R. Cortės;A. Probst;J. Palacios

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我们对8例无神经系统疾病的病人进行了脑干毒蕈碱胆碱能受体的定位研究,并对切片进行了定量放射自显影,结果清楚地表明,利用这些技术对人脑死后材料中毒蕈碱胆碱能受体进行定位和定量是可行的。此外,我们的研究结果表明,在许多脑干中心的正常功能,包括运动和感觉核,视觉和听觉中继核,心血管和泌尿相关核的乙酰胆碱的毒蕈碱胆碱能效应的潜在参与。
We have investigated the localization of muscarinic cholinergic receptors in the brainstem of eight patients free of neurological disease following quantitative autoradiography of microtome sectionsOur results thus clearly show the feasibility of using these techniques for the localization and quantification of muscarinic cholinergic receptors in human brain postmortem material. Furthermore, our findings indicate the potential involvement of the muscarinic cholinergic effect of acetylcholine in the normal function of many brainstem centers, including motor and sensory nuclei, visual and auditory relay nuclei and cardiovascular and respiratory-related nuclei.
胆碱和东莨菪碱在人类记忆中的相互作用。
DOI: 10.1016/0024-3205(85)90423-0
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