Mesotocin and nonapeptide receptors promote estrildid flocking behavior.

Mesotocin and nonapeptide receptors promote estrildid flocking behavior.
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DOI:
10.1126/science.1174929
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发表时间:
2009-08-14
期刊:
Science (New York, N.Y.)
影响因子:
--
通讯作者:
Kingsbury MA
Kingsbury MA
中科院分区:
其他
文献类型:
--
作者:
Goodson JL;Schrock SE;Klatt JD;Kabelik D;Kingsbury MA

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影响特定规模群体偏好的神经机制几乎是完全未知的。在高度群居的斑马雀中,催产素(OT)拮抗剂阻断非肽受体显著减少了与大型群体和熟悉的社会伴侣相处的时间,而不依赖于社会接触的时间。相反的作用是通过中央输注中胚素(MT;禽类OT同源物)产生的。大多数药物效应似乎都是女性特有的。在五种雌雀中,物种的典型群体大小与外侧隔区的非肽受体分布相关,雌性斑雀的社会性因向隔区注入OT拮抗剂而不是控制区而减少。我们认为,MT对社会性的滴定代表了OT在配对结合和母性功能中特定女性角色的进化的一个系统发育的深层框架。
Proximate neural mechanisms that influence preferences for groups of a given size are almost wholly unknown. In the highly gregarious zebra finch (Estrildidae: Taeniopygia guttata), blockade of nonapeptide receptors by an oxytocin (OT) antagonist significantly reduced time spent with large groups and familiar social partners, independent of time spent in social contact. Opposing effects were produced by central infusions of mesotocin (MT; avian OT homologue). Most drug effects appear to be female-specific. Across five estrildid finch species, species-typical group size correlates with nonapeptide receptor distributions in the lateral septum, and sociality in female zebra finches was reduced by OT antagonist infusions into the septum but not a control area. We propose that titration of sociality by MT represents a phylogenetically deep framework for the evolution of OT’s female-specific roles in pair bonding and maternal functions.
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