Association between early bronchiolitis and the development of childhood asthma: a meta-analysis.
Association between early bronchiolitis and the development of childhood asthma: a meta-analysis.
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早期细支气管炎与儿童哮喘发展之间的关联：一项荟萃分析
DOI：
10.1136/bmjopen-2020-043956
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发表时间：
2021-05-28
期刊：
影响因子：
2.9
通讯作者：
Liu L
中科院分区：
文献类型：
--
作者：
Wang G;Han D;Jiang Z;Li M;Yang S;Liu L
早期毛细支气管炎被假设为与随后的持续喘息或哮喘的风险相关。然而，这种联系仍然存在争议。本研究的目的是评估2岁以前的毛细支气管炎与晚发性喘息/哮喘之间的关系。系统回顾和荟萃分析.系统检索了PubMed、Embase和Web of Science数据库中1955年至2020年1月期间发表的研究。与此同时，我们也查阅了相关文献的参考文献列表，以了解这些参考文献是否包括可能符合审查条件的其他研究报告。评估早期毛细支气管炎和晚发性喘息/哮喘之间关系的队列和病例对照研究纳入本荟萃分析。数据由两名独立审查员提取。根据研究间的异质性，使用随机效应模型或固定效应模型汇总结果。纳入符合标准的32篇原始文献，292 844例受试者。2岁以前的细支气管炎与随后的喘息/哮喘的风险增加相关（相对风险= 2.46，95%CI 2.14 - 2.82，p <0.001）。在根据随访结束时的年龄、地理区域和研究质量将研究分类为不同的组后，这种关联仍然显着。荟萃分析表明2岁之前的细支气管炎与以后的喘息/哮喘之间存在关联。需要设计良好和高度标准化的前瞻性研究，更好地解决由于潜在混杂因素造成的偏倚，以验证我们荟萃分析中确定的风险。PROSPERO注册号CRD 42018089453。
Early life bronchiolitis has been hypothesised to be associated with the subsequent risk of persistent wheezing or asthma. However, the link remains controversial. The objective of our study was to evaluate the association between bronchiolitis before 2 years of age and the late-onset wheezing/asthma. Systematic review and meta-analysis. PubMed, Embase and Web of Science databases were systematically searched for studies published between 1955 and January 2020. Meanwhile, we also checked through the reference lists of relevant articles to see whether these references included reports of other studies that might be eligible for the review. Cohort and case–control studies assessing the association between early-life bronchiolitis and late-onset wheezing/asthma were included in this meta-analysis. Data were extracted by two independent reviewers. Results were pooled using a random-effects model or fixed-effects model according to the heterogeneity among studies. 32 original articles with 292 844 participants, which met the criteria, were included in this meta-analysis. Bronchiolitis before 2 years of age was associated with an increased risk of subsequent wheezing/asthma (relative risk=2.46, 95% CI 2.14 to 2.82, p<0.001). After categorising studies into different groups based on age at the end of follow-up, geographical region and study quality, the association still remained significant. The meta-analysis indicates an association between bronchiolitis before 2 years of age and the wheezing/asthma in later life. Well-designed and highly standardised prospective studies that better address bias due to potential confounding factors are needed to validate the risk identified in our meta-analysis. PROSPERO registration number CRD42018089453.
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影响因子：
7
作者：
Huedo-Medina, Tania B.;Sanchez-Meca, Julio;Botella, Juan
通讯作者：
Botella, Juan
影响因子：
3.7
作者：
Jeng MJ;Lee YS;Tsao PC;Yang CF;Soong WJ
通讯作者：
Soong WJ
DOI：
10.5588/ijtld.14.0170
发表时间：
2014-11-01
影响因子：
4
作者：
Asher, I.;Pearce, N.
通讯作者：
Pearce, N.
影响因子：
3.1
作者：
Jung, Young-Ho;Seo, Ju-Hee;Hong, Soo-Jong
通讯作者：
Hong, Soo-Jong
在挪威阿克斯胡斯县，婴儿期急性细支气管炎是喘息的危险因素，导致肺功能下降七年。
影响因子：
2.4
作者：
Fjaerli, Hans-Olav;Farstad, Teresa;Rod, Gisle;Ufert, Gunn Kristin;Gulbrandsen, Pal;Nakstad, Britt
通讯作者：
Nakstad, Britt