Emerging Technologies in Multi-Material Bioprinting.

Emerging Technologies in Multi-Material Bioprinting.
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DOI:
10.1002/adma.202104730
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发表时间:
2021-12
期刊:
Advanced materials (Deerfield Beach, Fla.)
影响因子:
--
通讯作者:
Zhang YS
Zhang YS
中科院分区:
其他
文献类型:
--
作者:
Ravanbakhsh H;Karamzadeh V;Bao G;Mongeau L;Juncker D;Zhang YS

文献摘要

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Bioprinting, within the emerging field of biofabrication, aims at the fabrication of functional biomimetic constructs. Different three-dimensional bioprinting techniques have been adapted to bioprint cell-laden bioinks. However, single-material bioprinting techniques oftentimes fail to reproduce the complex compositions and diversity of native tissues. Multi-material bioprinting as an emerging approach enables the fabrication of heterogeneous multi-cellular constructs that replicate their host microenvironments better than single-material approaches. Here, we briefly review bioprinting modalities, discuss how they are being adapted to multi-material bioprinting, as well as analyze their advantages and challenges, encompassing both custom-designed and commercially available technologies. The review offers a perspective of how multi-material bioprinting opens up new opportunities for tissue engineering, tissue model engineering, therapeutics development, and personalized medicine. A comprehensive overview of the available 3D bioprinting technologies for fabricating multi-material constructs is presented. The technologies are classified into four major categories, and their advantages and shortcomings are compared. Available multi-material commercial bioprinters are reviewed, concluding with a perspective of the future path for developing multi-material technologies.
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