Endocrine Disrupting Chemicals, Hormone Receptors, and Acne Vulgaris: A Connecting Hypothesis.
Endocrine Disrupting Chemicals, Hormone Receptors, and Acne Vulgaris: A Connecting Hypothesis.
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DOI：
10.3390/cells10061439
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发表时间：
2021-06-09
期刊：
影响因子：
6
通讯作者：
Hall JM
中科院分区：
文献类型：
--
作者：
Rao A;Douglas SC;Hall JM
内分泌干扰物（EDCs）和寻常痤疮的发病机制之间的关系尚未在文献中探讨。寻常痤疮是一种毛囊皮脂腺单位的慢性炎症性皮肤病。痤疮的发病机制涉及几种激素途径，包括雄激素、胰岛素样生长因子1（IGF-1）、雌激素和皮质类固醇。内分泌干扰物主要通过两种机制影响这些途径：改变内源性激素水平和干扰激素受体功能。这篇综述文章介绍了内分泌干扰物和痤疮病变的发展之间的机械联系。突出显示的是雄激素受体配体的贡献作用，如双酚A（BPA）和邻苯二甲酸单-2-乙基己酯（MEHP），通过上调脂肪生成基因和胆固醇合成的加剧。另外讨论了植物雌激素EDCs通过减弱PPARy转录活性（即，白藜芦醇）和恢复皮肤细胞中雌激素调节的TGF-β表达（即，染料木黄酮）。检查内分泌干扰物和寻常痤疮之间的关系可能会告知治疗的有效途径，例如限制环境暴露，以及在饮食中增加低血糖，富含植物的食物。随着对内分泌干扰物在痤疮中的累积作用的更好理解，临床医生可以更好地治疗并最终改善患者的生活。
The relationship between endocrine disrupting chemicals (EDCs) and the pathogenesis of acne vulgaris has yet to be explored in the literature. Acne vulgaris is a chronic inflammatory skin disease of the pilosebaceous unit. The pathogenesis of acne involves several hormonal pathways, including androgens, insulin-like growth factor 1(IGF-1), estrogens, and corticosteroids. EDCs influence these pathways primarily through two mechanisms: altering endogenous hormone levels and interfering with hormone receptor function. This review article describes the mechanistic links between EDCs and the development of acne lesions. Highlighted is the contributory role of androgen receptor ligands, such as bisphenol A (BPA) and mono-2-ethylhexyl Phthalate (MEHP), via upregulation of lipogenic genes and resultant exacerbation of cholesterol synthesis. Additionally discussed is the protective role of phytoestrogen EDCs in counteracting androgen-induced sebocyte maturation through attenuation of PPARy transcriptional activity (i.e., resveratrol) and restoration of estrogen-regulated TGF-B expression in skin cells (i.e., genistein). Examination of the relationship between EDCs and acne vulgaris may inform adjunctive avenues of treatment such as limiting environmental exposures, and increasing low-glycemic, plant-rich foods in the diet. With a better understanding of the cumulative role that EDCs play in acne, clinicians can be better equipped to treat and ultimately improve the lives of their patients.
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影响因子：
6.5
作者：
Hay, Roderick J.;Johns, Nicole E.;Naghavi, Mohsen
通讯作者：
Naghavi, Mohsen
DOI：
10.1038/jes.2008.44
发表时间：
2009-02
影响因子：
4.5
作者：
Cao, Yang;Calafat, Antonia M.;Doerge, Daniel R.;Umbach, David M.;Bernbaum, Judy C.;Twaddle, Nathan C.;Ye, Xiaoyun;Rogan, Walter J.
通讯作者：
Rogan, Walter J.
影响因子：
10.3
作者：
Ganceviciene, R.;Graziene, V.;Zouboulis, C. C.
通讯作者：
Zouboulis, C. C.
影响因子：
5.8
作者：
Banaszewska, Beata;Wrotynska-Barczynska, Joanna;Duleba, Antoni J.
通讯作者：
Duleba, Antoni J.
影响因子：
--
作者：
Chiu, A;Chon, SY;Kimball, AB
通讯作者：
Kimball, AB