Association of season of birth with DNA methylation and allergic disease.
Association of season of birth with DNA methylation and allergic disease.
复制标题
出生季节与DNA甲基化及过敏性疾病的关联
DOI：
10.1111/all.12882
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发表时间：
2016-09
期刊：
影响因子：
12.4
通讯作者：
Holloway JW
中科院分区：
文献类型：
--
作者：
Lockett GA;Soto-Ramírez N;Ray MA;Everson TM;Xu CJ;Patil VK;Terry W;Kaushal A;Rezwan FI;Ewart SL;Gehring U;Postma DS;Koppelman GH;Arshad SH;Zhang H;Karmaus W;Holloway JW
出生季节会影响过敏风险，但这一观察结果背后的生物学机制尚不清楚。环境影响DNA甲基化，对基因表达和疾病具有潜在的长期影响。这项研究调查了DNA甲基化是否可能是出生季节和过敏之间的联系的基础。在来自鬼魂岛出生队列的18岁参与者中(n=367)，估计了出生季节对过敏结果的风险。测量了全血表观基因组范围的DNA甲基化，并使用基于培训和测试的技术检测了与季节相关的CPGS。验证检查了8岁的哮喘和尘螨过敏的预防和发病率(PIAMA)队列。研究了DNA甲基化、出生季节与过敏反应的关系。分析了IoW第三代队列新生儿的CPG。与春季出生相比，秋季出生会增加患湿疹的风险。在表观基因组关联研究中，92CPGS的甲基化与出生季节有关。在验证中，更多的CPG偶然具有与预期相同的方向性，其中4个具有统计学意义。与季节相关的甲基化在与发育、细胞周期和细胞凋亡相关的网络中丰富。20个CPG名义上与过敏结果有关。两个CPG在导致过敏的原因路径上处于边缘。在新生儿中，与季节相关的甲基化在很大程度上是不存在的，这表明它发生在出生后。这项研究表明，成年期的DNA甲基化与出生季节有关，支持了DNA甲基化可能是出生季节对过敏影响的机械基础的假设，尽管其他机制也可能参与其中。
Season of birth influences allergy risk, however the biological mechanisms underlying this observation are unclear. The environment affects DNA methylation, with potentially long-lasting effects on gene expression and disease. This study examined whether DNA methylation could underlie the association between season of birth and allergy. In a subset of 18-year-old participants from the Isle of Wight (IoW) birth cohort (n=367), the risks of birth season on allergic outcomes were estimated. Whole blood epigenome-wide DNA methylation was measured, and season-associated CpGs detected using a training-and-testing-based technique. Validation examined the 8-year-old Prevention and Incidence of Asthma and Mite Allergy (PIAMA) cohort. The relationships between DNA methylation, season of birth and allergy were examined. CpGs were analysed in IoW third generation cohort newborns. Autumn birth increased risk of eczema, relative to spring birth. Methylation at 92 CpGs showed association with season of birth in the epigenome-wide association study. In validation significantly more CpGs had the same directionality than expected by chance, and four were statistically significant. Season-associated methylation was enriched among networks relating to development, the cell cycle, and apoptosis. Twenty CpGs were nominally associated with allergic outcomes. Two CpGs were marginally on the causal pathway to allergy. Season-associated methylation was largely absent in newborns, suggesting it arises postnatally. This study demonstrates that DNA methylation in adulthood is associated with season of birth, supporting the hypothesis that DNA methylation could mechanistically underlie the effect of season of birth on allergy, though other mechanisms are also likely to be involved.
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影响因子：
6.1
作者：
ARSHAD, SH;STEVENS, M;HIDE, DW
通讯作者：
HIDE, DW
影响因子：
3.6
作者：
HANAWA, Y;MAKI, M;SAWADA, K
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5.7
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Guthikonda K;Zhang H;Nolan VG;Soto-Ramírez N;Ziyab AH;Ewart S;Arshad HS;Patil V;Holloway JW;Lockett GA;Karmaus W
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Karmaus W
影响因子：
3.8
作者：
Lockett GA;Patil VK;Soto-Ramírez N;Ziyab AH;Holloway JW;Karmaus W
通讯作者：
Karmaus W
影响因子：
4.5
作者：
McGrath, JJ;Saha, S;Buka, S
通讯作者：
Buka, S