Magnetic resonance imaging metrics of oxygen extraction fraction: Contradictions or insight into pathophysiological mechanisms?
Magnetic resonance imaging metrics of oxygen extraction fraction: Contradictions or insight into pathophysiological mechanisms?
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DOI：
10.1002/ajh.26567
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发表时间：
2022-06-01
影响因子：
12.8
通讯作者：
Grant, P. Ellen
中科院分区：
文献类型：
--
作者：
Stout, Jeffrey N.;Lin, Pei-Yi;Sutin, Jason;Higgins, John;Grant, P. Ellen
在这一期的《美国血液学杂志》上，菲尔兹等人。报告使用不对称自旋回波磁共振成像(ASE-MRI)技术对一大群儿童(N=120)进行的脑氧提取分数(OEF)测量，其中包括健康对照组(34名)、无镰状细胞性贫血的贫血对照组(27名)和镰状细胞性贫血(SCA)组(59名)。1他们发现，贫血对照组的平均OEF显著高于健康对照组，而SCA组的OEF更高。此外，他们还发现，SCA患者OEF升高的脑体积比贫血对照组更大。在两个队列中，OEF增加最多的是白质，包括通过液体衰减反转恢复(FLAIR)MRI确定的梗塞区。在SCA中，与Vu等人最近报告的OEF下降相矛盾。VU等人。使用自旋标签下T2松弛磁共振成像(TRUSTMRI)测量了一大群年轻人(N=118)的OEF，其中包括健康对照组(44例)、贫血对照组(27例)和SCA患者(47例)。2本研究还发现贫血对照组的OEF与健康对照组不同，SCA的OEF差异更大，但差异是相反的，SCA的OEF最低。这种差异可能会导致读者对这两种方法不屑一顾，不知道哪种方法是正确的，但一旦考虑到每种测量技术的细节，这些相反的观察之间的和解是可能的。
In this issue of the American Journal of Hematology, Fields et al. report cerebral oxygen extraction fraction (OEF) measurements using an Asymmetric Spin Echo Magnetic Resonance Imaging (ASE-MRI) technique for a large cohort (N= 120) of children including healthy controls (34), anemic controls without sickle cell disease (27), and those with sickle cell anemia (SCA)(59). 1 They found that average OEF in anemic controls was significantly higher than in healthy controls, and that OEF is higher still in SCA. In addition, they found that the volume of brain with elevated OEF was larger for SCA than for anemic controls. In both cohorts, the largest OEF increases were in the white matter and included regions where infarcts were identified by fluid-attenuated inversion recovery (FLAIR) MRI.The observations of increased OEF by Fields et al. in SCA contradict the decreased OEF recently reported by Vu et al. Vu et al. used T2-relaxation under spin tagging MRI (TRUSTMRI) to measure OEF in a large cohort (N= 118) of young adults including healthy controls (44), anemic controls (27), and individuals with SCA (47). 2 This study also found that OEF in anemic controls differed from healthy controls and SCA had even larger OEF differences, however, the differences were in the opposite direction with SCA having the lowest OEF. This discrepancy could lead readers to dismiss both methods, not knowing which is correct, but once the details of each measurement technique are considered a reconciliation between these opposite observations is possible.
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影响因子：
3.3
作者：
Bush A;Vu C;Choi S;Borzage M;Miao X;Li W;Qin Q;Nederveen AJ;Coates TD;Wood JC
通讯作者：
Wood JC
DOI：
10.1073/pnas.1914056116
发表时间：
2019-12-10
影响因子：
11.1
作者：
Di Caprio, Giuseppe;Schonbrun, Ethan;Higgins, John M.
通讯作者：
Higgins, John M.
影响因子：
2.9
作者：
BENESCH, RE;EDALJI, R;BENESCH, R
通讯作者：
BENESCH, R
影响因子：
12.8
作者：
Vu C;Bush A;Choi S;Borzage M;Miao X;Nederveen AJ;Coates TD;Wood JC
通讯作者：
Wood JC
影响因子：
20.3
作者：
Fabry, ME;Desrosiers, L;Suzuka, SM
通讯作者：
Suzuka, SM