Risk Factors for Severe Hand-Foot-Mouth Disease in China: A Systematic Review and Meta-Analysis.
Risk Factors for Severe Hand-Foot-Mouth Disease in China: A Systematic Review and Meta-Analysis.
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中国严重手足口病的危险因素：系统回顾和荟萃分析
DOI：
10.3389/fped.2021.716039
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发表时间：
2021
影响因子：
2.6
通讯作者：
Hu D
中科院分区：
文献类型：
--
作者：
Li P;Huang Y;Zhu D;Yang S;Hu D
背景：本研究旨在确定严重手足口病(HFMD)的潜在危险因素。方法：检索PubMed、Embase、Cochrane图书馆、SINMED、万方、CNKI、VIP等数据库，直至2021年8月。结果：纳入29项研究(重症手足口病患者9,241例，对照组927,355例，均来自中国)。与其他药物相比，EV71与严重手足口病的风险更高(OR=4.44，95%CI：3.12~6.33，p<；0.001)。家庭抚养(OR=1.99，95%CI：1.5 9~2.5 0，p<；0.001)，有较多子女(OR=2.0 9，95%CI：1.93~2.2 7，p<；0.001)，手卫生差(OR=2.74，95%CI：1.78~4.2 3，p<；0.001)，无母乳喂养(OR=2.0 1，95%CI：1.45~2.79，p<；0.001)是严重手足口病的危险因素。首次就诊区级以上医院(OR=0.34，95%CI：0.25~0.45，p<；0.001)和基线诊断为手足口病(OR=0.17，95%CI：0.13~0.24，p<；0.001)是重症手足口病的保护因素。发热、长时间发热、呕吐、嗜睡、白细胞增多、抽搐和抽搐均与严重手足口病相关(均P<；0.05)，而皮疹则不相关。结论：肠道病毒71型、生活习惯、就诊次数和症状是中国地区儿童重症手足口病的危险因素，早期诊断和上级医院入院是保护性因素。
Background: This study aimed to identify potential risk factors for severe hand-foot-mouth disease (HFMD). Methods: The PubMed, Embase, the Cochrane Library, Sinomed, WanFang, CNKI, and VIP databases were searched (up to August 2021). Results: Twenty-nine studies (9,241 and 927,355 patients with severe HFMD and controls, respectively; all from China) were included. EV71 was associated with higher odds of severe HFMD compared with other agents (OR = 4.44, 95%CI: 3.12–6.33, p < 0.001). Being home-raised (OR = 1.99, 95%CI: 1.59–2.50, p < 0.001), higher number of children in the family (OR = 2.09, 95%CI: 1.93–2.27, p < 0.001), poor hand hygiene (OR = 2.74, 95%CI: 1.78–4.23, p < 0.001), and no breastfeeding (OR = 2.01, 95%CI: 1.45–2.79, p < 0.001) were risk factors for severe HFMD. First consulting to a district-level or above hospital (OR = 0.34, 95%CI: 0.25–0.45, p < 0.001) and diagnosis of HFMD at baseline (OR = 0.17, 95%CI: 0.13–0.24, p < 0.001) were protective factors against severe HFMD. Fever, long fever duration, vomiting, lethargy, leukocytosis, tic, and convulsions were each associated with severe HFMD (all p < 0.05), while rash was not. Conclusions: EV71, lifestyle habits, frequent hospital visits, and symptoms are risk factors for severe HFMD in children in China, while early diagnosis and admission to higher-level hospitals are protective factors.
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影响因子：
2.5
作者：
Chen, Shao-Ming;Du, Jian-Wei;Umezaki, Masahiro
通讯作者：
Umezaki, Masahiro
2012年中国沙沃肠道病毒71型感染及相关手足口病疫情特征
影响因子：
4.6
作者：
Liu MY;Liu J;Lai W;Luo J;Liu Y;Vu GP;Yang Z;Trang P;Li H;Wu J
通讯作者：
Wu J
影响因子：
1.9
作者：
Duval, S;Tweedie, R
通讯作者：
Tweedie, R
广东省环境因素与手足口病关联的贝叶斯时空分析
影响因子：
4.6
作者：
Du Z;Lawrence WR;Zhang W;Zhang D;Yu S;Hao Y
通讯作者：
Hao Y
DOI：
10.1016/0197-2456(86)90046-2
发表时间：
1986-09-01
期刊：
CONTROLLED CLINICAL TRIALS
影响因子：
--
作者：
DERSIMONIAN, R;LAIRD, N
通讯作者：
LAIRD, N