The Human Skin Volatolome: A Systematic Review of Untargeted Mass Spectrometry Analysis.
The Human Skin Volatolome: A Systematic Review of Untargeted Mass Spectrometry Analysis.
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DOI：
10.3390/metabo12090824
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发表时间：
2022-09-01
期刊：
影响因子：
4.1
通讯作者：
Hanna GB
中科院分区：
文献类型：
--
作者：
Mitra A;Choi S;Boshier PR;Razumovskaya-Hough A;Belluomo I;Spanel P;Hanna GB
挥发性有机化合物（VOC）的分析可以提供重要的临床信息（完全非侵入性）；然而，人类皮肤中的挥发性有机化合物在多大程度上可以成为健康和疾病的特征尚不清楚。本系统综述总结了有关皮肤 VOC 研究的方法、应用和挥发性特征的已发表文献。根据系统评价和荟萃分析的首选报告项目进行在线文献检索，以使用非靶向质谱（MS）方法识别人体皮肤VOC研究。主要结果是从皮肤中检测到经过化学验证的挥发性有机化合物。使用 CAS 编号与人类代谢组和 KEGG 数据库交叉引用每种 VOC，以评估生物起源。共有 29 项研究从 935 名参与者中鉴定出 822 种皮肤 VOC。通常使用吸收贴片 (n = 15) 从手 (n = 9) 或前臂 (n = 7) 采集皮肤 VOC，并通过气相色谱 MS 进行分析 (n = 23)。 22 项研究对健康受试者的皮肤 VOC 进行了分析，表明挥发性物质由醛 (18%)、羧酸 (12%)、烷烃 (12%)、脂肪醇 (9%)、酮 (7%)、苯及其衍生物 (6%)、烯烃 (2%) 和薄荷单萜 (2%) 组成。在已识别的 VOC 中，13% 具有假定的内源性来源，46% 具有暂定的外源性来源，40% 是来自混合代谢途径的代谢物。本综述全面描述了人体皮肤挥发物组学，证明了健康皮肤存在独特的 VOC 特征，这可以作为未来研究人员寻求释放皮肤挥发物组学临床潜力的参考。由于大部分已识别的 VOC 具有假定的外源来源，因此讨论了通过方法改进和识别混杂化合物来最大限度地减少其存在的策略。
The analysis of volatile organic compounds (VOCs) can provide important clinical information (entirely non-invasively); however, the exact extent to which VOCs from human skin can be signatures of health and disease is unknown. This systematic review summarises the published literature concerning the methodology, application, and volatile profiles of skin VOC studies. An online literature search was conducted in accordance with the preferred reporting items for systematic reviews and meta-analysis, to identify human skin VOC studies using untargeted mass spectrometry (MS) methods. The principal outcome was chemically verified VOCs detected from the skin. Each VOC was cross-referenced using the CAS number against the Human Metabolome and KEGG databases to evaluate biological origins. A total of 29 studies identified 822 skin VOCs from 935 participants. Skin VOCs were commonly sampled from the hand (n = 9) or forearm (n = 7) using an absorbent patch (n = 15) with analysis by gas chromatography MS (n = 23). Twenty-two studies profiled the skin VOCs of healthy subjects, demonstrating a volatolome consisting of aldehydes (18%), carboxylic acids (12%), alkanes (12%), fatty alcohols (9%), ketones (7%), benzenes and derivatives (6%), alkenes (2%), and menthane monoterpenoids (2%). Of the VOCs identified, 13% had putative endogenous origins, 46% had tentative exogenous origins, and 40% were metabolites from mixed metabolic pathways. This review has comprehensively profiled the human skin volatolome, demonstrating the presence of a distinct VOC signature of healthy skin, which can be used as a reference for future researchers seeking to unlock the clinical potential of skin volatolomics. As significant proportions of identified VOCs have putative exogenous origins, strategies to minimise their presence through methodological refinements and identifying confounding compounds are discussed.
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影响因子：
3.3
作者：
Liou GY;Storz P
通讯作者：
Storz P
影响因子：
16.1
作者：
Butler LM;Perone Y;Dehairs J;Lupien LE;de Laat V;Talebi A;Loda M;Kinlaw WB;Swinnen JV
通讯作者：
Swinnen JV
影响因子：
6.2
作者：
Jiang, Ruifen;Cudjoe, Erasmus;Pawliszyn, Janusz
通讯作者：
Pawliszyn, Janusz
影响因子：
3.6
作者：
Duffy, Emer;Jacobs, Matthew R.;Morrin, Aoife
通讯作者：
Morrin, Aoife
影响因子：
7.4
作者：
Adam, Mina E.;Fehervari, Matyas;Hanna, George B.
通讯作者：
Hanna, George B.