The inhibitory effect of a novel polypeptide fraction from Arca subcrenata on cancer-related inflammation in human cervical cancer HeLa cells.
The inhibitory effect of a novel polypeptide fraction from Arca subcrenata on cancer-related inflammation in human cervical cancer HeLa cells.
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Arca subcrenata 的新型多肽组分对人宫颈癌 HeLa 细胞癌症相关炎症的抑制作用
DOI：
10.1155/2014/768938
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发表时间：
2014
影响因子：
--
通讯作者：
Yu R
中科院分区：
文献类型：
--
作者：
Wu Y;Hu X;Song L;Zhu J;Yu R
众所周知，炎症与癌症的发展密切相关。本研究在人宫颈癌HeLa细胞中开展，以研究P2的抗肿瘤和抗炎作用，P2是一种来自重要渔业资源海蚶的海洋多肽组分。基础研究表明，P2可抑制lps诱导的RAW264.7巨噬细胞一氧化氮的产生以及人宫颈癌HeLa细胞炎症因子IL-6和TNF-α的分泌。分子机制方面，P2下调HeLa细胞中促炎因子IL-6和IL-8的基因表达，抑制COX-2和inos相关通路。因此，P2可能通过阻断肿瘤微环境与促炎介质之间的相互作用来抑制肿瘤的发展。这些结果表明，P2具有作为一种新型癌症治疗药物的潜力。
Inflammation is known to be closely associated with the development of cancer. The study was launched in human cervical cancer HeLa cells to investigate the antitumor and anti-inflammatory effects of P2, a marine polypeptide fraction from an important fishery resource Arca subcrenata. The basic research showed that P2 could suppress the production of nitric oxide in LPS-induced RAW264.7 macrophage cells as well as the secretion of inflammatory cytokines IL-6 and TNF-α in human cervical cancer HeLa cells. For the molecular mechanisms, P2 was shown to downregulate the gene expression of proinflammatory cytokines IL-6 and IL-8 and to inhibit the COX-2 and iNOS-related pathways in HeLa cells. In consequence, P2 might inhibit tumor development by blocking the interaction between tumor microenvironment and proinflammatory mediators. All findings indicate that P2 possesses the potential to be developed as a novel agent for cancer therapy.
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影响因子：
2.6
作者：
Holmes K;Egan B;Swan N;O'Morain C
通讯作者：
O'Morain C
影响因子：
5.4
作者：
Song L;Li T;Yu R;Yan C;Ren S;Zhao Y
通讯作者：
Zhao Y
影响因子：
2.9
作者：
GREEN, LC;WAGNER, DA;TANNENBAUM, SR
通讯作者：
TANNENBAUM, SR
DOI：
10.1093/jnci/90.6.455
发表时间：
1998-03-18
期刊：
JOURNAL OF THE NATIONAL CANCER INSTITUTE
影响因子：
--
作者：
Hwang, D;Scollard, D;Levine, E
通讯作者：
Levine, E
影响因子：
6.2
作者：
Costanzo, ES;Lutgendorf, SK;Lubaroff, DM
通讯作者：
Lubaroff, DM