African, Native American, and European mitochondrial DNAs in Cubans from Pinar del Rio Province and implications for the recent epidemic neuropathy in Cuba
African, Native American, and European mitochondrial DNAs in Cubans from Pinar del Rio Province and implications for the recent epidemic neuropathy in Cuba
复制标题
比那尔德里奥省古巴人的非洲、美洲原住民和欧洲线粒体 DNA 及其对古巴最近流行性神经病的影响
作者：
A. Torroni;Michael D. Brown;M. Lott;N. Newman;D. Wallace
遗传易感性，特别是特定的线粒体DNA（mtDNA）背景，已被认为是自1991年以来影响古巴居民的双侧视神经病变流行病的一个促成因素。为了证实或反驳特定的mtDNA亚群可能参与疾病表达的可能性，我们利用了古巴人口的异质性种族起源和最近鉴定出的一些mtDNA多态性，这些多态性似乎是非洲人，美洲原住民和欧洲人特有的。对来自比那尔德尔里奥省的流行性神经病患者和对照组进行这些多态性的筛选，结果显示，非洲人、美洲原住民和欧洲人的mtDNA单倍型在病例组和对照组中的代表性相等，并表明约50%的古巴人mtDNA来自欧洲人，46%来自非洲人，4%来自美洲原住民。这些研究结果表明，突变中出现的spic mtDNA是不太可能发挥作用的流行性神经病，并表明mtDNA单倍型分析可以是一个有价值的工具，用于评估非洲人，美洲原住民和欧洲人在混合人群中的相对孕产妇的贡献。© 1995 Wiley利斯公司
Genetic predisposition, particularly specific mitochondrial DNA (mtDNA) backgrounds, has been proposed as a contributing factor in the expression of an epidemic of bilateral optic neuropathy that has affected residents of Cuba since 1991. To substantiate or refute the possibility that specific subsets of mtDNAs could participate in disease expression, we took advantage of the heterogeneous ethnic origin of the Cuban population and the recent identification of a number of mtDNA polymorphisms that appear to be specific for Africans, Native Americans, and Europeans. The screening of both carefully selected people with epidemic neuropathy and control subjects from the Pinar del Rio Province for these polymorphisms revealed that African, Native American, and European mtDNA haplotypes were equally represented among case and control subjects, and suggested that ∼ 50% of Cuban mtDNAs originated from Europeans, 46% from Africans, and 4% from Native Americans. These findings demonstrate that mutations arising in spic mtDNAs are unlikely to play a role in the epidemic neuropathy and indicate that analysis of mtDNA haplotypes can be a valuable tool for assessing the relative maternal contribution of Africans, Native Americans, and Europeans in a mixed population. © 1995 Wiley‐Liss, Inc.
登录
查看更多内容
影响因子：
9.8
作者：
A. Torroni;R. Sukernik;T. Schurr;B. Starikovskaya;Margaret F. Cabell;M. Crawford;A. Comuzzie;D. Wallace
通讯作者：
A. Torroni;R. Sukernik;T. Schurr;B. Starikovskaya;Margaret F. Cabell;M. Crawford;A. Comuzzie;D. Wallace
美洲人的线粒体 DNA“时钟”及其对他们进入北美的计时的影响。
DOI：
10.1073/pnas.91.3.1158
发表时间：
1994
影响因子：
11.1
作者：
Torroni,A;Neel,JV;Barrantes,R;Schurr,TG;Wallace,DC
通讯作者：
Wallace,DC
墨西哥南部四个美洲原住民群体的 mtDNA 和 Y 染色体多态性。
影响因子：
9.8
作者：
Torroni,A;Chen,YS;Semino,O;Santachiara-Beneceretti,AS;Scott,CR;Lott,MT;Winter,M;Wallace,DC
通讯作者：
Wallace,DC
巴布亚新几内亚人类线粒体 DNA 的地理变异。
影响因子：
3.3
作者：
Stoneking,M;Jorde,LB;Bhatia,K;Wilson,AC
通讯作者：
Wilson,AC
影响因子：
2.8
作者：
TORRONI, A;MILLER, JA;WALLACE, DC
通讯作者：
WALLACE, DC