Hippocampal activation during contextual fear inhibition related to resilience in the early aftermath of trauma.
Hippocampal activation during contextual fear inhibition related to resilience in the early aftermath of trauma.
复制标题
在创伤早期的早期，在上下文恐惧抑制期间，海马激活与弹性有关。
DOI：
10.1016/j.bbr.2021.113282
复制
发表时间：
2021-06-25
影响因子：
2.7
通讯作者：
Stevens JS
中科院分区：
文献类型：
--
作者：
van Rooij SJH;Ravi M;Ely TD;Michopoulos V;Winters SJ;Shin J;Marin MF;Milad MR;Rothbaum BO;Ressler KJ;Jovanovic T;Stevens JS
背景恐惧抑制功能受损通常与创伤后应激障碍（PTSD）有关。我们以前的工作已经证明，在创伤暴露后的反应抑制任务中，更多的海马激活与更大的恢复力和更少的未来PTSD症状有关。在目前的研究中，我们试图通过采用情境恐惧条件反射和消退范式来扩展我们以前的研究结果，以进一步确定海马在创伤后早期恢复力和PTSD中的作用。参与者（N=28）在经历创伤事件后不久在急诊室招募。在创伤后约两个月在3 T MRI扫描仪中进行情境恐惧抑制任务。收集了扫描时的恢复力（CD-RISC）和创伤后三个月的PTSD症状。研究人员评估了海马激活在恐惧条件反射过程中和在灭绝过程中的背景效应过程中，以及创伤后恢复力和三个月时的PTSD症状之间的关联。在恐惧条件反射过程中，双侧海马感兴趣区（ROI）的激活与恢复力呈正相关（r=0.48，p=0.01）。在消退过程中的背景效应中，在控制基线PTSD症状、年龄和性别后，创伤后3个月，双侧海马激活程度越高，PTSD症状越低（r=-0.59，p=0.009）。更大的海马激活与创伤后恢复力和创伤后三个月的创伤后应激障碍症状有关。目前的研究支持并加强了先前的研究结果，表明依赖于校园的背景处理作为恢复力与PTSD风险的机制的重要性，这可能是新的早期干预的潜在机制目标。
Impaired contextual fear inhibition is often associated with posttraumatic stress disorder (PTSD). Our previous work has demonstrated that more hippocampal activation during a response inhibition task after trauma exposure was related to greater resilience and fewer future PTSD symptoms. In the current study, we sought to extend our previous findings by employing a contextual fear conditioning and extinction paradigm to further determine the role of the hippocampus in resilience and PTSD in the early aftermath of trauma. Participants (N=28) were recruited in the Emergency Department shortly after experiencing a traumatic event. A contextual fear inhibition task was conducted in a 3T MRI scanner approximately two months post-trauma. Measures of resilience (CD-RISC) at time of scan and PTSD symptoms three months post-trauma were collected. The associations between hippocampal activation during fear conditioning and during the effect of context during extinction, and post-trauma resilience and PTSD symptoms at three-months were assessed. During fear conditioning, activation of the bilateral hippocampal region of interest (ROI) correlated positively with resilience (r=0.48, p=0.01). During the effect of context during extinction, greater bilateral hippocampal activation correlated with lower PTSD symptoms three months post-trauma after controlling for baseline PTSD symptoms, age and gender (r=−0.59, p=0.009). Greater hippocampal activation was related to post-trauma resilience and lower PTSD symptoms three months post-trauma. The current study supports and strengthens prior findings suggesting the importance of hippocampus-dependent context processing as a mechanism for resilience versus PTSD risk, which could be a potential mechanistic target for novel early interventions.
登录
查看更多内容
影响因子：
4.7
作者：
Jovanovic T;Kazama A;Bachevalier J;Davis M
通讯作者：
Davis M
影响因子：
3
作者：
Jin J;Maren S
通讯作者：
Maren S
影响因子：
3.6
作者：
Jovanovic, Tanja;Ely, Tim;Fani, Negar;Glover, Ebony M.;Gutman, David;Tone, Erin B.;Norrholm, Seth D.;Bradley, Bekh;Ressler, Kerry J.
通讯作者：
Ressler, Kerry J.
影响因子：
7.4
作者：
Connor, KM;Davidson, JRT
通讯作者：
Davidson, JRT
影响因子：
19.9
作者：
Fanselow, Michael S.
通讯作者：
Fanselow, Michael S.