Associations between Dietary Nutrient Intakes and Hepatic Lipid Contents in NAFLD Patients Quantified by ¹H-MRS and Dual-Echo MRI.
Associations between Dietary Nutrient Intakes and Hepatic Lipid Contents in NAFLD Patients Quantified by ¹H-MRS and Dual-Echo MRI.
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通过 H-1-MRS 和双回波 MRI 量化 NAFLD 患者膳食营养素摄入量与肝脏脂质含量之间的关联
DOI：
10.3390/nu8090527
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发表时间：
2016-08-27
期刊：
影响因子：
5.9
通讯作者：
Feng R
中科院分区：
文献类型：
--
作者：
Cheng Y;Zhang K;Chen Y;Li Y;Li Y;Fu K;Feng R
饮食习惯对于肝脏脂质堆积和非酒精性脂肪肝（NAFLD）的进展至关重要。然而，使用 1H 磁共振波谱 (1H-MRS) 和双回波同相和异相磁共振波谱成像 (双回波 MRI) 来评估膳食营养素摄入对肝脏脂质含量的影响的研究有限。在本研究中，我们招募了 36 名成年女性（NAFLD：对照 = 19：17）接受问卷调查和体检，包括饮食摄入量、人体测量和生化测量、1H-MRS 和双回声 MRI 检查。研究发现 NAFLD 患者饮食中能量、蛋白质、脂肪、饱和脂肪酸 (SFA) 和多不饱和脂肪酸 (PUFA) 含量较高。调整年龄和体重指数（BMI）后，总能量摄入与肝脂肪分数（HFF）和肝内脂质（IHL）呈正相关（HFF：β = 0.24，p = 0.02；IHL：β = 0.38，p = 0.02）。调整年龄、BMI 和总能量摄入后，总脂肪摄入量与 HFF 和 IHL 呈正相关（HFF：β = 0.36，p = 0.03；IHL：β = 0.42，p = 0.01）。调整后，SFA 摄入量与 HFF 和 IHL 呈正相关（HFF：β = 0.45，p = 0.003；IHL：β = 1.16，p = 0.03）。总之，肝脏脂肪含量与高能量、高脂肪和高 SFA 摄入量相关，通过 1H-MRS 和双回波 MRI 在我们的人群中进行量化。我们的研究结果有助于提供预防肝脏脂质积累和 NAFLD 的饮食目标。
Dietary habits are crucial in the progression of hepatic lipid accumulation and nonalcoholic fatty liver disease (NAFLD). However, there are limited studies using 1H-magnetic resonance spectroscopy (1H-MRS) and dual-echo in-phase and out-phase magnetic resonance spectroscopy imaging (dual-echo MRI) to assess the effects of dietary nutrient intakes on hepatic lipid contents. In the present study, we recruited 36 female adults (NAFLD:control = 19:17) to receive questionnaires and medical examinations, including dietary intakes, anthropometric and biochemical measurements, and 1H-MRS and dual-echo MRI examinations. NAFLD patients were found to consume diets higher in energy, protein, fat, saturated fatty acid (SFA), and polyunsaturated fatty acid (PUFA). Total energy intake was positively associated with hepatic fat fraction (HFF) and intrahepatic lipid (IHL) after adjustment for age and body-mass index (BMI) (HFF: β = 0.24, p = 0.02; IHL: β = 0.38, p = 0.02). Total fat intake was positively associated with HFF and IHL after adjustment for age, BMI and total energy intake (HFF: β = 0.36, p = 0.03; IHL: β = 0.42, p = 0.01). SFA intake was positively associated with HFF and IHL after adjustments (HFF: β = 0.45, p = 0.003; IHL: β = 1.16, p = 0.03). In conclusion, hepatic fat content was associated with high energy, high fat and high SFA intakes, quantified by 1H-MRS and dual-echo MRI in our population. Our findings are useful to provide dietary targets to prevent the hepatic lipid accumulation and NAFLD.
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影响因子：
64.8
作者：
HERVEY, GR
通讯作者：
HERVEY, GR
影响因子：
7.1
作者：
Mollard, Rebecca C.;Senechal, Martin;McGavock, Jonathan M.
通讯作者：
McGavock, Jonathan M.
影响因子：
5.9
作者：
Li YC;Li CL;Qi JY;Huang LN;Shi D;Du SS;Liu LY;Feng RN;Sun CH
通讯作者：
Sun CH
影响因子：
158.5
作者：
GRUNDY, SM
通讯作者：
GRUNDY, SM
DOI：
10.1002/jmri.1880050311
发表时间：
1995-05-01
期刊：
JMRI-JOURNAL OF MAGNETIC RESONANCE IMAGING
影响因子：
--
作者：
LONGO, R;POLLESELLO, P;DALLAPALMA, L
通讯作者：
DALLAPALMA, L