T Regulatory and T Helper 17 Cells in Primary Sjögren's Syndrome: Facts and Perspectives.
T Regulatory and T Helper 17 Cells in Primary Sjögren's Syndrome: Facts and Perspectives.
复制标题
原发性Sjögren综合征中的调节和T辅助17个细胞：事实和观点。
DOI：
10.1155/2015/243723
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发表时间：
2015
影响因子：
4.6
通讯作者：
Gerli R
中科院分区：
文献类型：
--
作者：
Alunno A;Carubbi F;Bistoni O;Caterbi S;Bartoloni E;Mirabelli G;Cannarile F;Cipriani P;Giacomelli R;Gerli R
长期以来，原发性干燥综合征(PSS)被认为是一种由T辅助细胞(H)1引起的疾病，这是由于患者靶器官和外周血中的CD4+T淋巴细胞及其产物占主导地位。在过去的几十年里，包括Th17、T调节T细胞(Treg)和滤泡辅助T细胞在内的许多T细胞亚群的鉴定挑战了这一长期存在的范式，并促使人们认识到它们在PSS发病机制中的作用。此外，IL-6、IL-17、IL-22、IL-23等致炎细胞因子异常产生的影响也引起了相当大的关注。然而，尽管已经在PSS的实验模型和患者中进行了一些研究，但关于Treg细胞和IL-17/Th17细胞系统在PSS发病机制中的许多方面还没有完全阐明。特别是，不同的产生IL-17的T细胞亚群所起的作用以及药物治疗对Treg/Th17细胞平衡的影响是一个有趣的问题。这篇综述文章的目的是提供关于PSS发病机制中Treg细胞和产生IL-17的T细胞的最新知识。我们相信，这些对PSS发病机制的洞察可能为成功的治疗干预提供基础。
Historically, primary Sjögren's syndrome (pSS) was thought to be a T helper (h) 1 driven disease due to the predominance of CD4+T lymphocytes and their products in target organs and peripheral blood of patients. In the last decades, the identification of a number of T cell subsets, including Th17, T regulatory (Treg), and follicular helper T cells, challenged this long-standing paradigm and prompted to identify their role in pSS pathogenesis. In addition the impact of abnormal proinflammatory cytokine production, such as IL-6, IL-17, IL-22, and IL-23, has also attracted considerable attention. However, although several studies have been carried out in experimental models and patients with pSS, many aspects concerning the role of Treg cells and IL-17/Th17 cell system in pSS pathogenesis are not fully elucidated. In particular, the role played by different IL-17-producing T cell subsets as well as the effects of pharmacological therapies on Treg/Th17 cell balance represents an intriguing issue. The aim of this review article is to provide an overview of current knowledge on Treg cells and IL-17-producing T cells in pSS pathogenesis. We believe that these insights into pSS pathogenesis may provide the basis for successful therapeutic intervention in this disease.
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影响因子：
3.5
作者：
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通讯作者：
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作者：
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通讯作者：
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