Incessant ovulation: a review of its importance in predicting cancer risk.
Incessant ovulation: a review of its importance in predicting cancer risk.
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DOI：
10.3389/fonc.2023.1240309
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发表时间：
2023
影响因子：
4.7
通讯作者：
中科院分区：
文献类型：
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作者：
发情周期是由雌性激素、黄体酮和其他激素引起的哺乳动物反复发生的变化，最终导致子宫内膜增殖、排卵和受精后的着床。对女性来说，发情周期就是月经周期；但是，与大多数哺乳动物不同的是，不孕症周期的结束以子宫内膜脱落为标志，另一个周期的开始没有发情期。女性在更年期停止循环，而在大多数哺乳动物中，循环一直持续到死亡。流行病学研究发现，月经初潮、更年期、分娩、哺乳期和口服避孕药（OC）的使用是卵巢癌、乳腺癌和子宫内膜癌的关键危险因素。创建了一个复合变量来估计未被停止排卵事件中断的周期数量。重复周期被称为“不间断排卵”，最初被认为会影响卵巢癌的风险，后来扩展到乳腺癌和子宫内膜癌。这些关联可以解释为生殖器官内重复组织变化的累积效应，通过糖蛋白粘蛋白1重复排卵的免疫后果，以及过去排卵增强卵巢睾酮产生的残留效应。后两种途径可能会影响其他非“生殖”器官患癌症的风险。
Estrous cycles are recurring changes in therian mammals induced by estrogen, progesterone, and other hormones culminating in endometrial proliferation, ovulation, and implantation if fertilization occurred. In women, the estrous cycle is the menstrual cycle; but, unlike most mammals, the end of an infertile cycle is marked by endometrial sloughing and the start of another without an anestrous phase. Women stop cycling at menopause, while in most mammals, cycles continue until death. Epidemiologic studies identified menarche, menopause, births, lactation, and oral contraceptive (OC) use as key risk factors for ovarian, breast, and endometrial cancers. A composite variable was created to estimate the number of cycles not interrupted by events that stop ovulation. Captured by the phrase “incessant ovulation”, repetitive cycles were first postulated to affect ovarian cancer risk and later extended to breast and endometrial cancers. These associations could be explained by cumulative effects of repetitive tissue changes within reproductive organs, immune consequences of repetitive ovulation through the glycoprotein mucin 1, and residual effects of past ovulations that enhance ovarian production of testosterone. The latter two pathways could affect the risk for cancers in other organs not considered “reproductive”.
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DOI：
10.1002/ijgo.13737
发表时间：
2022-03
期刊：
International journal of gynaecology and obstetrics: the official organ of the International Federation of Gynaecology and Obstetrics
影响因子：
--
作者：
通讯作者：
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影响因子：
6.4
作者：
Felix, Ashley S.;Gaudet, Mia M.;La Vecchia, Carlo;Nagle, Christina M.;Shu, Xiao Ou;Weiderpass, Elisabete;Adami, Hans Olov;Beresford, Shirley;Bernstein, Leslie;Chen, Chu;Cook, Linda S.;De Vivo, Immaculata;Doherty, Jennifer A.;Friedenreich, Christine M.;Gapstur, Susan M.;Hill, Dierdre;Horn-Ross, Pamela L.;Lacey, James V.;Levi, Fabio;Liang, Xiaolin;Lu, Lingeng;Magliocco, Anthony;McCann, Susan E.;Negri, Eva;Olson, Sara H.;Palmer, Julie R.;Patel, Alpa V.;Petruzella, Stacey;Prescott, Jennifer;Risch, Harvey A.;Rosenberg, Lynn;Sherman, Mark E.;Spurdle, Amanda B.;Webb, Penelope M.;Wise, Lauren A.;Xiang, Yong-Bing;Xu, Wanghong;Yang, Hannah P.;Yu, Herbert;Zeleniuch-Jacquotte, Anne;Brinton, Louise A.
通讯作者：
Brinton, Louise A.
影响因子：
3.8
作者：
Chavez-MacGregor, M;Elias, SG;Peeters, PHM
通讯作者：
Peeters, PHM
影响因子：
3.8
作者：
Chavez-MacGregor, Mariana;van Gils, Carla H.;Peeters, Petra H. M.
通讯作者：
Peeters, Petra H. M.
影响因子：
2.3
作者：
Allil, Paulo A. A.;Visconti, Maria A.;Isoldi, Mauro C.
通讯作者：
Isoldi, Mauro C.