Systematic review and meta-analysis on the impact of the levonorgestrel-releasing intrauterine system in reducing risk of ovarian cancer.
Systematic review and meta-analysis on the impact of the levonorgestrel-releasing intrauterine system in reducing risk of ovarian cancer.
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DOI：
10.1002/ijgo.13737
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发表时间：
2022-03
期刊：
影响因子：
--
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中科院分区：
文献类型：
--
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卵巢癌（OC）是世界上最常见的肿瘤之一，其特点是生存率低。确定左炔诺孕酮宫内释放系统（LNG-IUS）是否可以预防OC。根据PRISMA系统性综述报告声明（PROSPERO：CRD 42019137957），对截至2020年12月的文献进行了系统性综述。纳入了评估LNG-IUS对OC风险影响的研究。数据由两位作者独立提取，以确保准确性和一致性。共获得34323份记录，其中3份符合纳入标准。在20 461 311人-年的人群中，共考虑了1687起OC事件。数据汇总显示，相对于从未使用LNG-IUS，使用LNG-IUS并未降低OC的风险，估计比值比为0.66（95%置信区间0.41-1.08; I2 = 84%; P = 0.002）。Meta分析未证明LNG-IUS对OC的预防作用。然而，它是在几篇论文上进行的，仍然不能就这一专题得出明确的结论。未来将进行进一步研究，以确定LNG-IUS对OC的影响。对3篇论文进行的Meta分析未证明左炔诺孕酮释放宫内节育器对卵巢癌的预防作用。
Ovarian carcinoma (OC) is one of the most widespread tumors in the world and is characterized by low survival rates. To determine whether the levonorgestrel‐releasing intrauterine system (LNG‐IUS) can prevent OC. The literature until December 2020 were systematically reviewed according to the PRISMA Statement for Reporting Systematic Reviews (PROSPERO: CRD42019137957). Studies assessing the impact of LNG‐IUS on the risk of OC were included. Data were extracted independently by two authors to ensure accuracy and consistency. A total of 34 323 records were obtained, of which three satisfied the inclusion criteria. In total, 1687 events of OC in a population of 20 461 311 person‐years were considered. Data pooling revealed that the use of LNG‐IUS did not confer a lower risk of OC relative to the never‐use of LNG‐IUS, with an estimated odds ratio of 0.66 (95% confidence interval 0.41–1.08; I2 = 84%; P = 0.002). The meta‐analysis did not demonstrate a preventive role of LNG‐IUS on OC. However, it was carried out on a few papers, and a definitive conclusion on the topic still cannot be drawn. Further studies are indicated in the future to define the impact of LNG‐IUS on OC. The meta‐analysis carried out on three papers did not demonstrate a preventive role of the levonorgestrel‐releasing intrauterine device on ovarian cancer.
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影响因子：
3.2
作者：
NILSSON, CG;HAUKKAMAA, M;LUUKKAINEN, T
通讯作者：
LUUKKAINEN, T
影响因子：
5.6
作者：
Cramer, Daniel W.;Xu, Huijuan
通讯作者：
Xu, Huijuan
影响因子：
168.9
作者：
Beral, V.;Doll, R.;Risch, H. A.
通讯作者：
Risch, H. A.
卵巢癌和卵巢癌：因果关系，临床意义和“靶向预防”。
影响因子：
1.5
作者：
Crum CP;McKeon FD;Xian W
通讯作者：
Xian W
DOI：
10.1016/0197-2456(86)90046-2
发表时间：
1986-09-01
期刊：
CONTROLLED CLINICAL TRIALS
影响因子：
--
作者：
DERSIMONIAN, R;LAIRD, N
通讯作者：
LAIRD, N