Occupational exposure to neurotoxic substances in Asian countries - challenges and approaches.
Occupational exposure to neurotoxic substances in Asian countries - challenges and approaches.
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DOI：
10.1016/j.neuro.2011.12.012
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发表时间：
2012-08
期刊：
影响因子：
3.4
通讯作者：
Kang SK
中科院分区：
文献类型：
--
作者：
Meyer-Baron M;Kim EA;Nuwayhid I;Ichihara G;Kang SK
在中国举行的一次神经毒性会议引发了一个想法，即深入了解职业病、其发展情况以及在亚洲国家调查职业病的方法。历史回顾，荟萃分析，以及对人类和动物的研究提供了对过去和当前问题的印象。韩国的例子表明，每一个新引进的产业都有其自身的职业病问题。汞和二硫化碳在开始时很重要，而溶剂和锰后来变得很重要。疾病的爆发是引导公众和政府注意预防的重要原因，并使在相对较短的时间内取得了相当大的进展。正如用1-溴丙烷取代2-溴丙烷的例子所表明的那样，采用对环境更有利的化学品也可能导致额外的职业风险。在日本的研究中，1-溴罂粟烷的致突变性较低，但神经毒性较高。虽然职业健康和疾病通常与成年人有关，但黎巴嫩的一项研究对接触溶剂的童工进行了调查。这项研究开始概述年轻工人的健康危害，因为他们的神经系统尚未完全成熟，可能面临更大的风险。关于农药的研究表明，一些职业病尚未成为预防的重点。如果有的话，对过度接触造成的严重健康后果进行了调查。国际文献中没有关于采取预防行动的研究。尽管全球化，但有关职业病的知识尚未“全球化”，每个国家显然都在经历由当地经验引发的自身发展。经济发展需要健康的劳动力，但公共利益也对政府法规提出挑战，进一步努力预防职业病。这篇论文反映了在“亚洲国家的职业神经毒性”研讨会上发表的演讲摘要，该研讨会是第11届职业和环境健康神经行为方法和影响国际研讨会的一部分。
The fact that a conference on neurotoxicity was held in China triggered the idea to provide an insight into occupational diseases, their development and the approaches to investigate them in Asian countries. A historical review, a meta-analysis, and studies on humans and animals provide impressions on past and current problems. The Korean example showed that each newly introduced industry is accompanied by its own problems as regards occupational diseases. Mercury and carbon disulfide were of importance in the beginning, whereas solvents and manganese became important later. Outbreaks of diseases were important reasons to guide both the public and the governmental attention to prevention and allowed within a relatively short time considerable progress. As the example on the replacement of 2-bromopropane by 1-bromopropane showed, also the introduction of chemicals that are more beneficial for the environment may result in additional occupational risks. A lower mutagenicity of 1-bromopopane was shown to be associated with a greater neurotoxicity in Japanese studies. Although occupational health and diseases are commonly related to adults, child workers exposed to solvents were examined in a Lebanese study. The study started outlining the health hazards in young workers because they might be at a much greater risk due to the not yet completed maturation of their nervous system. That some occupational diseases are not yet a focus of prevention was shown by the study on pesticides. If at all, the serious health consequences resulting from excessive exposure were investigated. Research enabling precautionary actions was not available from the international literature. Despite globalization the knowledge on occupational diseases is not yet “globalized” and each country obviously undergoes its own development triggered by local experiences. Economic development that requires a healthy workforce, but also public interest that challenges governmental regulations further efforts on the prevention of occupational diseases. The paper reflects a summary of the talks presented at the symposium “Occupational Neurotoxicities in Asian Countries” as part of the 11th International Symposium on Neurobehavioral Methods and Effects in Occupational and Environmental Health.
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影响因子：
6.3
作者：
Delgado, E;McConnell, R;Wesseling, C
通讯作者：
Wesseling, C
影响因子：
3
作者：
Ichihara, G;Miller, JK;Takeuchi, Y
通讯作者：
Takeuchi, Y
影响因子：
3.8
作者：
Ichihara, G;Kitoh, J;Takeuchi, Y
通讯作者：
Takeuchi, Y
1-溴丙烷工厂工人的神经系统异常。
影响因子：
10.4
作者：
Ichihara G;Li W;Shibata E;Ding X;Wang H;Liang Y;Peng S;Itohara S;Kamijima M;Fan Q;Zhang Y;Zhong E;Wu X;Valentine WM;Takeuchi Y
通讯作者：
Takeuchi Y
影响因子：
8.2
作者：
Andersen, SL
通讯作者：
Andersen, SL