Hippocampal context processing is critical for interference free recall of odor memories in rats.
Hippocampal context processing is critical for interference free recall of odor memories in rats.
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DOI：
10.1002/hipo.20953
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发表时间：
2012-04
期刊：
影响因子：
3.5
通讯作者：
Smith, David M.
中科院分区：
文献类型：
--
作者：
Butterly, Dan A.;Petroccione, Maurice A.;Smith, David M.
干扰是记忆系统的一个重要问题，也是导致检索失败的主要原因。减少干扰的一个策略是把要记住的东西和它们学习的环境联系起来。例如，在不同的环境中学习两个单词列表的人类受试者比在同一环境中学习两个单词列表的受试者受到的干扰更少，记忆力也更好。海马体长期以来一直被认为参与处理上下文信息，最近的研究表明，海马体神经元表现出上下文独特的放电模式，可以作为上下文的神经表征。这些观察结果表明，海马体背景处理可能在克服干扰方面发挥关键作用。为了验证这一假设，我们将基于上下文的列表学习过程应用于大鼠。对照大鼠和海马体暂时损伤的大鼠在相同或不同的环境中接受了两组8对气味的训练。为了引起干扰，一些气味出现在两个列表中，但它们的预测值相反。与人类实验对象一样，在不同环境中学习这两个列表的大鼠比在相同环境中学习列表的大鼠表现得好得多。然而，海马体病变完全消除了这种情境学习优势。我们还通过使用不包含任何常见项目的列表来训练老鼠进行低干扰版本的任务。有趣的是，当学习环境不涉及高水平的干扰时，海马损伤的大鼠完全没有受损。这些发现与海马体编码环境的观点一致，并进一步表明海马体的环境编码是有益的，因为它提供了一种克服干扰的方法。
Interference is a critical problem for memory systems and a primary cause of retrieval failure. One strategy for minimizing interference is to associate the items to be remembered with the context in which they were learned. For example, human subjects who learn two lists of words in separate contexts experience less interference and better recall than subjects who learn both lists in the same context. The hippocampus has long been known to be involved in processing contextual information and recent studies have shown that hippocampal neurons exhibit context-unique firing patterns that could serve as a neural representation of the context. These observations suggest that hippocampal context processing may play a critical role in overcoming interference. To test this hypothesis, we adapted the context based list learning procedure for use with rats. Control rats and rats given temporary lesions of the hippocampus were trained on two lists of eight odor pairs, either in the same context or in different contexts. In order to induce interference, some of the odors appeared on both lists with their predictive value reversed. As with human subjects, rats that learned the two lists in different contexts performed significantly better than rats that learned the lists in the same context. However, hippocampal lesions completely abolished this contextual learning advantage. We also trained rats on a low interference version of the task by using lists that did not contain any common items. Interestingly, rats with hippocampal lesions were entirely unimpaired when the learning situation did not involve high levels of interference. These findings are consistent with the idea that the hippocampus encodes contexts and further suggest that hippocampal context coding is beneficial because it provides a means of overcoming interference.
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DOI：
10.1016/s0091-6773(74)92231-7
发表时间：
1974-01-01
期刊：
BEHAVIORAL BIOLOGY
影响因子：
--
作者：
HIRSH, R
通讯作者：
HIRSH, R
DOI：
10.1073/pnas.94.13.7109
发表时间：
1997-06-24
影响因子：
11.1
作者：
Dusek, JA;Eichenbaum, H
通讯作者：
Eichenbaum, H
影响因子：
5.3
作者：
Eacott, MJ;Norman, G
通讯作者：
Norman, G
影响因子：
1.9
作者：
Dusek, JA;Eichenbaum, H
通讯作者：
Eichenbaum, H
影响因子：
56.9
作者：
KIM, JJ;FANSELOW, MS
通讯作者：
FANSELOW, MS