Interactions between metabolic, reward and cognitive processes in appetite control: Implications for novel weight management therapies.
Interactions between metabolic, reward and cognitive processes in appetite control: Implications for novel weight management therapies.
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DOI：
10.1177/0269881117736917
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发表时间：
2017-11
期刊：
影响因子：
--
通讯作者：
Dourish CT
中科院分区：
文献类型：
--
作者：
Higgs S;Spetter MS;Thomas JM;Rotshtein P;Lee M;Hallschmid M;Dourish CT
传统的食欲控制模型强调平行的内稳态和享乐系统的作用，但最近，独立的内稳态和享乐系统之间的区别已经被抛弃，而倾向于强调两个系统的神经化学底物之间的相互作用的框架。此外，最近出现的证据表明，更高层次的认知功能，如学习、记忆和注意力，在日常食欲控制中起着重要作用，而体内平衡信号也在认知中发挥作用。在这里，我们回顾了这些证据，并提出了一个综合的食欲控制模型，包括认知、体内平衡和奖励机制。我们讨论了该模型对理解可能导致饮食失调的因素的影响，并提出了开发更有效的饮食失调和体重管理治疗方法的机会。
Traditional models of appetite control have emphasised the role of parallel homeostatic and hedonic systems, but more recently the distinction between independent homeostatic and hedonic systems has been abandoned in favour of a framework that emphasises the cross talk between the neurochemical substrates of the two systems. In addition, evidence has emerged more recently, that higher level cognitive functions such as learning, memory and attention play an important role in everyday appetite control and that homeostatic signals also play a role in cognition. Here, we review this evidence and present a comprehensive model of the control of appetite that integrates cognitive, homeostatic and reward mechanisms. We discuss the implications of this model for understanding the factors that may contribute to disordered patterns of eating and suggest opportunities for developing more effective treatment approaches for eating disorders and weight management.
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影响因子：
3.7
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