Functionalizing designer DNA crystals with a triple-helical veneer.
Functionalizing designer DNA crystals with a triple-helical veneer.
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DOI：
10.1002/anie.201309914
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发表时间：
2014-04-07
影响因子：
16.6
通讯作者：
Seeman, Nadrian C.
中科院分区：
文献类型：
--
作者：
Rusling, David A.;Chandrasekaran, Arun Richard;Ohayon, Yoel P.;Brown, Tom;Fox, Keith R.;Sha, Ruojie;Mao, Chengde;Seeman, Nadrian C.
DNA是一种非常有用的分子，用于2D和3D纳米级物体的程序化自组装。这些结构的设计利用沃森-克里克杂交和链交换将线性双链体缝合成有限的组装体。这些复合物的尺寸可以通过粘性单链片段（粘性末端）的自组装增加超过五个数量级。利用DNA纳米结构的序列可寻址性的方法将使组件在2D和3D空间中的可编程定位成为可能，提供诸如纳米电子学的组织、生物级联的方向以及通过X射线衍射确定周期性定位分子的结构等应用。为此，我们提出了一个宏观的3D晶体的基础上的3倍旋转对称的张拉整体三角形，可以功能化的三链体形成的寡核苷酸在其每个螺旋边缘。
DNA is a very useful molecule for the programmed self-assembly of 2D and 3D nanoscale objects. The design of these structures exploits Watson–Crick hybridization and strand exchange to stitch linear duplexes into finite assemblies. The dimensions of these complexes can be increased by over five orders of magnitude through self-assembly of cohesive single-stranded segments (sticky ends). Methods that exploit the sequence addressability of DNA nanostructures will enable the programmable positioning of components in 2D and 3D space, offering applications such as the organization of nanoelectronics, the direction of biological cascades, and the structure determination of periodically positioned molecules by X-ray diffraction. To this end we present a macroscopic 3D crystal based on the 3-fold rotationally symmetric tensegrity triangle that can be functionalized by a triplex-forming oligonucleotide on each of its helical edges.
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影响因子：
15
作者：
Liu, D;Wang, MS;Mao, CD
通讯作者：
Mao, CD
影响因子：
15
作者：
Wang, Tong;Sha, Ruojie;Birktoft, Jens;Zheng, Jianping;Mao, Chengde;Seeman, Nadrian C.
通讯作者：
Seeman, Nadrian C.
影响因子：
14.9
作者：
Rusling DA;Powers VE;Ranasinghe RT;Wang Y;Osborne SD;Brown T;Fox KR
通讯作者：
Fox KR
影响因子：
64.8
作者：
Rothemund, PWK
通讯作者：
Rothemund, PWK
影响因子：
16.6
作者：
Seeman NC
通讯作者：
Seeman NC