Nanomaterials based on DNA.

Nanomaterials based on DNA.
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DOI:
10.1146/annurev-biochem-060308-102244
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发表时间:
2010
影响因子:
16.6
通讯作者:
Seeman NC
Seeman NC
中科院分区:
生物学1区
文献类型:
--
作者:
Seeman NC

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在过去的30年里,合成的稳定的分支DNA和粘性末端的结合导致了结构DNA纳米技术的发展。这项事业的基础是,通过在自组装协议中结合这些特征,可以构建新的基于DNA的材料。因此,简单的分支分子直接导致多面体的构建,其边缘由双螺旋DNA组成,其顶点对应于分支点。较硬的分支基序可用于产生DNA的自组装二维和三维周期性晶格(晶体)。DNA还被用来制造各种纳米机械装置,包括改变形状的分子,以及可以沿着DNA人行道行走的分子。装置已被纳入二维DNA排列;序列依赖性装置是由增加核苷酸配对在其机器周期的每一步。
The combination of synthetic stable branched DNA and sticky ended cohesion has led to the development of structural DNA nanotechnology over the past 30 years. The basis of this enterprise is that it is possible to construct novel DNA-based materials by combining these features in a self-assembly protocol. Thus, simple branched molecules lead directly to the construction of polyhedra whose edges consist of double helical DNA, and whose vertices correspond to the branch points. Stiffer branched motifs can be used to produce self-assembled two-dimensional and three-dimensional periodic lattices of DNA (crystals). DNA has also been used to make a variety of nanomechanical devices, including molecules that change their shapes, and molecules that can walk along a DNA sidewalk. Devices have been incorporated into two-dimensional DNA arrangements; sequence-dependent devices are driven by increases in nucleotide pairing at each step in their machine cycles.
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