The trajectory of gait speed preceding mild cognitive impairment.
The trajectory of gait speed preceding mild cognitive impairment.
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DOI：
10.1001/archneurol.2010.159
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发表时间：
2010-08
影响因子：
--
通讯作者：
Kaye, Jeffrey
中科院分区：
文献类型：
--
作者：
Buracchio, Teresa;Dodge, Hiroko H.;Howieson, Diane;Wasserman, Dara;Kaye, Jeffrey
比较轻度认知功能障碍（MCI）患者和认知功能完好患者的运动功能下降轨迹（通过步态速度和手指敲击速度测量）。我们还试图确定那些发展MCI的人运动功能加速下降的大致时间。纵向队列研究受试者为来自俄勒冈州脑老化研究的204名健康老年人（58%为女性），每年进行神经学、神经心理学和运动检查，评估长达20年。使用混合效应模型比较了运动功能随年龄增长而下降的模式，该模型具有年龄和轻度认知功能障碍临床诊断的相互作用项。在MCI诊断之前的时间，当步态或敲击速度的变化加速时，采用混合效应模型进行评估，该模型具有男性和女性的变化点，分别和组合，发展MCI。MCI转换者和非转换者的步态速度（p<0.001）和优势手（p<0.003）、非优势手（p<0.001）的叩击速度的增龄变化率有显著性差异。使用MCI转换器的变点分析，在MCI发作前12.1年，步态速度的降低加速了0.02 m/s/yr（p<0.001）。步态速度下降的加速发生在男性比女性早。对于敲击速度，男女组合时，优势手和非优势手的变化点都发生在MCI发作后。在MCI发生前12年，以步态速度为指标的运动功能下降加速。运动功能的纵向变化可能有助于在临床前阶段早期发现痴呆，此时疾病修饰疗法的效用最大。
To compare the trajectory of motor decline, as measured by gait speed and finger tapping speed, between those who developed mild cognitive impairment (MCI) and those who remained cognitively intact. We also sought to determine the approximate time at which decline in motor function accelerated in those who developed MCI. Longitudinal cohort study Subjects were 204 healthy seniors (58% women) from the Oregon Brain Aging Study evaluated for up to 20 years with annual neurologic, neuropsychological and motor examinations. The pattern of motor decline with aging was compared using a mixed-effects model with an interaction term for age and clinical diagnosis of mild cognitive impairment. The time prior to diagnosis of MCI when the change in gait or tapping speed accelerates was assessed with a mixed-effects model with a change point for men and women, separately and combined, who developed MCI. The rates of change with aging of gait speed (p<0.001) and tapping speed in the dominant hand (p<0.003) and non-dominant hand (p<0.001) were significantly different between MCI converters and non-converters. Using a change-point analysis for MCI converters, the decrease in gait speed accelerated by 0.02 m/s/yr (p<0.001) occurring 12.1 years prior to the onset of MCI. An acceleration of gait speed decline occurred earlier in men than women. For tapping speed, the change point occurred after the onset of MCI for both dominant and non-dominant hands when men and women were combined. Motor decline as indexed by gait speed accelerates up to 12 years prior to MCI. Longitudinal changes in motor function may be useful in the early detection of dementia during pre-clinical stages when the utility of disease-modifying therapies would be greatest.
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影响因子：
1.8
作者：
Hausdorff, Jeffrey M.;Doniger, Glen M.;Simon, Ely S.
通讯作者：
Simon, Ely S.
影响因子：
14
作者：
Hayes, Tamara L.;Abendroth, Francena;Adami, Andre;Pavel, Misha;Zitzelberger, Tracy A.;Kaye, Jeffrey A.
通讯作者：
Kaye, Jeffrey A.
影响因子：
9.9
作者：
Buchman, Aron S.;Schneider, Julie A.;Bennett, David A.
通讯作者：
Bennett, David A.
DOI：
10.1097/00005072-199712000-00011
发表时间：
1997-12-01
影响因子：
3.2
作者：
Gearing, M;Levey, AI;Mirra, SS
通讯作者：
Mirra, SS
影响因子：
11.2
作者：
Schneider, JA;Li, JL;Bennett, DA
通讯作者：
Bennett, DA