The allergenicity of complex cations.

The allergenicity of complex cations.
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复杂阳离子的致敏性。

DOI:
10.1016/0006-291x(86)90966-6
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发表时间:
1986
影响因子:
3.1
通讯作者:
Wood,JM
Wood,JM
中科院分区:
生物学4区
文献类型:
--
作者:
Schallreuter,KU;Wood,JM

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一系列同源的八个季铵盐(季铵盐)被用作复合阳离子在豚鼠接触性超敏反应的调查。两个测试的季被发现是强过敏原,这是由于在表皮细胞表面的膜脂质的稳定协会。这种表面络合反应进行了详细研究,通过使用自旋标记的季中间变应原性。电子自旋共振显示,稳定的“离子对”之间形成的膜受体网站和两个强过敏原。获得了关于免疫原性复合物形成的特异性和动力学以及这些半抗原在体内表皮受体位点上的位置和方向的信息。
A homologous series of eight quaternary ammonium salts (quats) were used as complex cations in a survey of contact hypersensitivity in guinea pigs. Two of the quats tested were found to be strong allergens which was due to stable association with membrane lipids at the surface of epidermal cells. This surface complexation reaction was studied in detail by using a spin-labelled quat of intermediate allergenicity. Electron spin resonance was used to show that stable “ion pairs” are formed between membrane receptor sites and the two strong allergens. Information was obtained on the specificity and kinetics of immunogenic complex formation as well as on the position and orientation of these haptens on epidermal receptor sites in vivo.
DOI: 10.1136/bmj.284.6313.417-a
发表时间: 1982
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影响因子: --
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影响因子: 4.1
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发表时间: 1971
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