Transmission of influenza virus via aerosols and fomites in the guinea pig model.

Transmission of influenza virus via aerosols and fomites in the guinea pig model.
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DOI:
10.1086/597073
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发表时间:
2009-03-15
期刊:
The Journal of infectious diseases
影响因子:
--
通讯作者:
Palese P
Palese P
中科院分区:
其他
文献类型:
--
作者:
Mubareka S;Lowen AC;Steel J;Coates AL;García-Sastre A;Palese P

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关于流感病毒不同传播途径的相对贡献,现有数据有限。人与人之间的传播是季节性和大流行性传播的核心;然而,传播方式是一个持续辩论的问题。解决这一问题对于在卫生保健和社区环境中制定有效的控制措施至关重要。使用豚鼠模型,我们证明了A/Panama/2007/1999(H3 N2)流感病毒通过空气传播是有效的,与通过污染的环境表面(污染物)传播相比。我们还检查了2种人流感病毒A株的气溶胶传播效率,发现在我们的模型中,A/Panama/2007/1999流感病毒比A/Texas/36/1991(H1N1)病毒传播效率更高。这些数据提供了新的和急需的见解流感病毒传播的模式和株特异性差异的传播效率
Limited data on the relative contributions of different routes of transmission for influenza virus are available. Person-to-person transmission is central to seasonal and pandemic spread; nevertheless, the modes of spread are a matter of ongoing debate. Resolution of this discussion is paramount to the development of effective control measures in health care and community settings. Using the guinea pig model, we demonstrated that transmission of influenza A/Panama/2007/1999 (H3N2) virus through the air is efficient, compared with spread through contaminated environmental surfaces (fomites). We also examined the aerosol transmission efficiencies of 2 human influenza virus A strains and found that A/Panama/2007/1999 influenza virus transmitted more efficiently than A/Texas/36/1991 (H1N1) virus in our model. The data provide new and much-needed insights into the modes of influenza virus spread and strain-specific differences in the efficiency of transmission
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