Calvarial Suture-Derived Stem Cells and Their Contribution to Cranial Bone Repair.
Calvarial Suture-Derived Stem Cells and Their Contribution to Cranial Bone Repair.
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DOI：
10.3389/fphys.2017.00956
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发表时间：
2017
影响因子：
4
通讯作者：
Liu KJ
中科院分区：
文献类型：
--
作者：
Doro DH;Grigoriadis AE;Liu KJ
除了生命中的自然周转外，骨骼中的骨骼还具有自我修复能力，以应对损伤或疾病相关的骨丢失。基于对骨缺损模型的研究，这两个过程在很大程度上都得到了常驻干细胞的支持。多年来，在长骨中，骨骼干细胞的来源已得到广泛研究，其中主要的干细胞群被认为位于骨髓的血管周围生态位中。相比之下，我们对干细胞有助于颅骨修复的知识非常有限。事实上，直到最近，成人颅面骨中特定干细胞的存在还不确定。这些扁平骨主要通过膜内骨化而不是软骨内骨化形成，因此包含最小的骨髓空间。先前已经提出，上覆的骨膜和下伏的硬脑膜为颅骨修复提供骨祖细胞。尽管如此，最近的研究已经确定了一个主要的干细胞群体内的缝间充质具有多种分化能力和内在的修复潜力。在这里，我们提供了一个更新的审查颅骨干细胞和潜在的调节机制的背景下，颅骨损伤修复。
In addition to the natural turnover during life, the bones in the skeleton possess the ability to self-repair in response to injury or disease-related bone loss. Based on studies of bone defect models, both processes are largely supported by resident stem cells. In the long bones, the source of skeletal stem cells has been widely investigated over the years, where the major stem cell population is thought to reside in the perivascular niche of the bone marrow. In contrast, we have very limited knowledge about the stem cells contributing to the repair of calvarial bones. In fact, until recently, the presence of specific stem cells in adult craniofacial bones was uncertain. These flat bones are mainly formed via intramembranous rather than endochondral ossification and thus contain minimal bone marrow space. It has been previously proposed that the overlying periosteum and underlying dura mater provide osteoprogenitors for calvarial bone repair. Nonetheless, recent studies have identified a major stem cell population within the suture mesenchyme with multiple differentiation abilities and intrinsic reparative potential. Here we provide an updated review of calvarial stem cells and potential mechanisms of regulation in the context of skull injury repair.
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影响因子：
3
作者：
Homayounfar N;Park SS;Afsharinejad Z;Bammler TK;MacDonald JW;Farin FM;Mecham BH;Cunningham ML
通讯作者：
Cunningham ML
影响因子：
7.7
作者：
Isern J;García-García A;Martín AM;Arranz L;Martín-Pérez D;Torroja C;Sánchez-Cabo F;Méndez-Ferrer S
通讯作者：
Méndez-Ferrer S
影响因子：
5.2
作者：
Grcevic, Danka;Pejda, Slavica;Matthews, Brya G.;Repic, Dario;Wang, Liping;Li, Haitao;Kronenberg, Mark S.;Jiang, Xi;Maye, Peter;Adams, Douglas J.;Rowe, David W.;Aguila, Hector L.;Kalajzic, Ivo
通讯作者：
Kalajzic, Ivo
影响因子：
15.3
作者：
Arai, F;Ohneda, O;Suda, T
通讯作者：
Suda, T
影响因子：
--
作者：
Chen CW;Corselli M;Péault B;Huard J
通讯作者：
Huard J