Beyond Calories: An Integrated Approach to Promote Health, Longevity, and Well-Being.
Beyond Calories: An Integrated Approach to Promote Health, Longevity, and Well-Being.
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超越卡路里：促进健康，长寿和福祉的综合方法。
作者：
Bertozzi B;Tosti V;Fontana L
1948年，世界卫生组织将健康定义为“身体、精神和社会的完全健康状态，而不仅仅是没有疾病或虚弱”。批评者声称，这种健康的定义是乌托邦式的，不现实的。然而，越来越多的实验研究证据表明，衰老与慢性疾病的发展并不必然相关，与年龄相关的分子损伤积累可以通过下调关键细胞营养感应途径的饮食和遗传操作来预防或大大延迟。然而，为了获得完整的身体，精神和社会福祉，我们作为人类需要超越营养或药物治疗，并实施综合干预措施，不仅增强我们的代谢健康，而且增强我们的心理，情感，智力和精神发展，我们的社会关系和文化福祉。这一观点强调了一系列以科学研究为基础的干预措施，这些干预措施有可能用于促进人类健康和长寿。我们还将简要讨论环境健康在实现这一目标方面的重要性。
In 1948, the World Health Organization defined health as “a state of complete physical, mental, and social well-being, and not merely the absence of disease or infirmity”. Detractors claim that this definition of health is utopian and unrealistic. However, accumulating evidence from experimental studies suggest that aging is not inevitably linked with the development of chronic diseases, and age-associated accumulation of molecular damage can be prevented or greatly delayed by dietary and genetic manipulations that down-regulate key cellular nutrient-sensing pathways. Nonetheless, to obtain a state of complete physical, mental, and social well-being, we as human beings need to go beyond nutrition or pharmacological treatments, and implement a combination of interventions that enhance not only our metabolic health, but also our psychological, emotional, intellectual and spiritual development, our social relationships and cultural well-being. This perspective highlights a range of scientific research-based interventions that can potentially be used to promote human health and longevity. We will also briefly address the importance of environmental health in achieving this goal.
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