Quantitative resistance can lead to evolutionary changes in traits not targeted by the resistance QTLs.
Quantitative resistance can lead to evolutionary changes in traits not targeted by the resistance QTLs.
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DOI：
10.1111/eva.12130
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发表时间：
2014-03
影响因子：
4.1
通讯作者：
van de Bosch F
中科院分区：
文献类型：
--
作者：
Van den Berg F;Lannou C;Gilligan CA;van de Bosch F
本文解决了植物病理学中普遍关注的问题，即在景观中引入数量抗性会导致致病性增加。在此，我们研究了数量性状位点（QTL）作用于单位病变面积病原体孢子产量的假设情况。为了恢复其原始适应度，病原体可以破坏QTL，恢复其孢子生产能力，从而增加每个病变的孢子产量。或者，它可以增加其病变大小，也导致每个病变的孢子产量增加。数据分析表明，每个病灶的孢子产量（受抗性QTL影响）和病灶大小（非QTL靶向）是正相关性状，这表明非QTL靶向性状（病灶大小）的大小变化可能间接影响目标性状（每个病灶的孢子产量）。其次，我们模拟了病原体适应对病变大小增加的影响，并分析了其对每个病变孢子产量的影响。模型计算表明，当病原体无法克服抗性相关的QTL时，它可能通过间接选择在抗性和易感品种上增加致病性来补偿其适应度降低，但QTL仍然有效。
This paper addresses the general concern in plant pathology that the introduction of quantitative resistance in the landscape can lead to increased pathogenicity. Hereto, we study the hypothetical case of a quantitative trait loci (QTL) acting on pathogen spore production per unit lesion area. To regain its original fitness, the pathogen can break the QTL, restoring its spore production capacity leading to an increased spore production per lesion. Or alternatively, it can increase its lesion size, also leading to an increased spore production per lesion. A data analysis shows that spore production per lesion (affected by the resistance QTL) and lesion size (not targeted by the QTL) are positively correlated traits, suggesting that a change in magnitude of a trait not targeted by the QTL (lesion size) might indirectly affect the targeted trait (spore production per lesion). Secondly, we model the effect of pathogen adaptation towards increased lesion size and analyse its consequences for spore production per lesion. The model calculations show that when the pathogen is unable to overcome the resistance associated QTL, it may compensate for its reduced fitness by indirect selection for increased pathogenicity on both the resistant and susceptible cultivar, but whereby the QTLs remain effective.
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影响因子：
4.1
作者：
Pariaud B;Berg F;Bosch F;Powers SJ;Kaltz O;Lannou C
通讯作者：
Lannou C
影响因子：
5.3
作者：
Chung CL;Longfellow JM;Walsh EK;Kerdieh Z;Van Esbroeck G;Balint-Kurti P;Nelson RJ
通讯作者：
Nelson RJ
影响因子：
3.2
作者：
Gonzalez, Ana M.;Marcel, Thierry C.;Niks, Rients E.
通讯作者：
Niks, Rients E.
DOI：
10.1098/rspb.2000.1100
发表时间：
2000-05-22
影响因子：
4.7
作者：
Gandon, S;Michalakis, Y
通讯作者：
Michalakis, Y
影响因子：
9.4
作者：
Jorge, V;Dowkiw, A;Bastien, C
通讯作者：
Bastien, C