Post-acute sequelae of covid-19 six to 12 months after infection: population based study.
Post-acute sequelae of covid-19 six to 12 months after infection: population based study.
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DOI：
10.1136/bmj-2022-071050
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发表时间：
2022-10-13
影响因子：
105.7
通讯作者：
Kern, Winfried, V
中科院分区：
文献类型：
--
作者：
Peter, Raphael S.;Nieters, Alexandra;Krausslich, Hans-Georg;Brockmann, Stefan O.;Gopel, Siri;Kindle, Gerhard;Merle, Uta;Steinacker, Jurgen M.;Rothenbacher, Dietrich;Kern, Winfried, V
描述急性感染后6至12个月的症状和症状群，描述危险因素，并检查症状群与总体健康和工作能力的关系。在2020年10月至2021年3月期间，向德国南部四个地理上确定的地区的卫生当局通报了确诊的SARS-CoV-2感染的18-65岁成年人。50457名患者被邀请参加该研究，其中12053名（24%）回应，11710名（58.8% (n=6881)）女性；平均年龄44.1岁；3.6%（412/11 602）曾因covid-19入院；平均随访时间8.5个月)可纳入分析。症状频率（急性感染后6至12个月与急性感染前相比）、症状严重程度和聚集性、危险因素以及与总体健康恢复和工作能力的关系。疲劳（37.2%(4213/11 312)，95%可信区间36.4% ~ 38.1%）和神经认知功能障碍（31.3%(3561/11 361),30.5% ~ 32.2%）是导致健康恢复和工作能力下降的主要症状，但胸部症状、焦虑/抑郁、头痛/头晕和疼痛综合征也普遍存在，与工作能力有关，性别和年龄存在一定差异。考虑到至少中度日常生活障碍的新症状和≤80%的一般健康或工作能力恢复，在参与者中，covid后综合征的总体估计为28.5%(3289/11 536,27.7%至29.3%)，或在感染的成年人群中至少为6.5%(3289/50 457)（假设所有无反应者完全康复）。真实的价值很可能介于这些估计之间。尽管应答率较低，可能存在选择和回忆偏差，但本研究表明，急性SARS-CoV-2感染后6至12个月，自述急性后症状聚集和可能的后遗症（特别是疲劳和神经认知障碍）负担相当大，即使在轻度感染后的中青年成年人中也是如此，对总体健康和工作能力产生重大影响。德国临床研究注册DRKS 00027012。
To describe symptoms and symptom clusters of post-covid syndrome six to 12 months after acute infection, describe risk factors, and examine the association of symptom clusters with general health and working capacity. Population based, cross sectional study Adults aged 18-65 years with confirmed SARS-CoV-2 infection between October 2020 and March 2021 notified to health authorities in four geographically defined regions in southern Germany. 50 457 patients were invited to participate in the study, of whom 12 053 (24%) responded and 11 710 (58.8% (n=6881) female; mean age 44.1 years; 3.6% (412/11 602) previously admitted with covid-19; mean follow-up time 8.5 months) could be included in the analyses. Symptom frequencies (six to 12 months after versus before acute infection), symptom severity and clustering, risk factors, and associations with general health recovery and working capacity. The symptom clusters fatigue (37.2% (4213/11 312), 95% confidence interval 36.4% to 38.1%) and neurocognitive impairment (31.3% (3561/11 361), 30.5% to 32.2%) contributed most to reduced health recovery and working capacity, but chest symptoms, anxiety/depression, headache/dizziness, and pain syndromes were also prevalent and relevant for working capacity, with some differences according to sex and age. Considering new symptoms with at least moderate impairment of daily life and ≤80% recovered general health or working capacity, the overall estimate for post-covid syndrome was 28.5% (3289/11 536, 27.7% to 29.3%) among participants or at least 6.5% (3289/50 457) in the infected adult population (assuming that all non-responders had completely recovered). The true value is likely to be between these estimates. Despite the limitation of a low response rate and possible selection and recall biases, this study suggests a considerable burden of self-reported post-acute symptom clusters and possible sequelae, notably fatigue and neurocognitive impairment, six to 12 months after acute SARS-CoV-2 infection, even among young and middle aged adults after mild infection, with a substantial impact on general health and working capacity. German registry of clinical studies DRKS 00027012.
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影响因子：
3.2
作者：
Mantovani E;Mariotto S;Gabbiani D;Dorelli G;Bozzetti S;Federico A;Zanzoni S;Girelli D;Crisafulli E;Ferrari S;Tamburin S
通讯作者：
Tamburin S
COVID-19 的 50 多种长期影响：系统回顾和荟萃分析。
影响因子：
4.6
作者：
Lopez-Leon S;Wegman-Ostrosky T;Perelman C;Sepulveda R;Rebolledo PA;Cuapio A;Villapol S
通讯作者：
Villapol S
DOI：
10.1016/j.bbih.2022.100454
发表时间：
2022-05
期刊：
Brain, behavior, & immunity - health
影响因子：
--
作者：
Hall PA;Meng G;Hudson A;Sakib MN;Hitchman SC;MacKillop J;Bickel WK;Fong GT
通讯作者：
Fong GT
影响因子：
15.1
作者：
Hampshire A;Trender W;Chamberlain SR;Jolly AE;Grant JE;Patrick F;Mazibuko N;Williams SC;Barnby JM;Hellyer P;Mehta MA
通讯作者：
Mehta MA
影响因子：
11.8
作者：
Seessle, Jessica;Waterboer, Tim;Merle, Uta
通讯作者：
Merle, Uta