Biomonitoring programs in Michigan, Minnesota and New York to assess human exposure to Great Lakes contaminants.

Biomonitoring programs in Michigan, Minnesota and New York to assess human exposure to Great Lakes contaminants.
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DOI:
10.1016/j.ijheh.2018.08.012
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发表时间:
2019-01
影响因子:
6
通讯作者:
Ragin-Wilson A
Ragin-Wilson A
中科院分区:
医学2区
文献类型:
--
作者:
Wattigney WA;Irvin-Barnwell E;Li Z;Davis SI;Manente S;Maqsood J;Scher D;Messing R;Schuldt N;Hwang SA;Aldous KM;Lewis-Michl EL;Ragin-Wilson A

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在过去的一个世纪里,工业化和城市实践导致五大湖生态系统--世界上最大的地表淡水系统--受到污染,为4000多万居民提供饮用水和娱乐。2010年,启动了恢复五大湖倡议,以加快保护和恢复五大湖及其周边地区的努力。在GLRI的资助下,有毒物质和疾病登记机构发起了五大湖人口生物监测(BGLP)计划。该计划的目标是通过测量潜在易感人群中污染物的身体负担来评估人类对五大湖遗留和新出现的污染物的暴露情况。BGLP计划包括与由ATSDR资助的州合作开展的一系列横断面研究。第一个BGLP计划(BGLP-I)始于2010年,通过与密歇根州、明尼苏达州和纽约州的州卫生部门达成合作协议,于2015年9月完成。这三个州的计划针对的是居住在指定污染区域的易感成年人。在所有人群中测量的污染物包括汞、铅、灭蚁灵、六氯苯、二氯二苯基三氯乙烷和选定的多氯联苯同系物。此外,还在几个人群中测量了一些新出现的令人关注的化学品,如全氟烷基物质和多氟烷基物质。生物监测结果有助于指导公共卫生行动,以减轻这些脆弱的五大湖人口中的化学品暴露。我们提供了BGLP-I项目的研究人群、设计和一般方法的概述。这一概述为后续手稿提供了一个引子,这些手稿介绍了居住在七个关注领域的文化多样性易感人群--即海岸线垂钓者、运动垂钓者、美国印第安人和缅甸移民--中遗留和新出现的污染物的人类生物监测数据。
Over the past century, industrialization and urban practices have resulted in the contamination of the Great Lakes ecosystem—the world's largest surface freshwater system—that provides drinking water and recreation to more than 40 million residents. In 2010, the Great Lakes Restoration Initiative was launched to accelerate efforts to protect and restore the Great Lakes and surrounding areas. Funded by GLRI, the Agency for Toxic Substances and Disease Registry initiated the Biomonitoring of Great Lakes Populations (BGLP) program. The objective of the program is to assess human exposure to legacy and emerging contaminants in the Great Lakes by measuring the body burden of contaminants in potentially susceptible populations. The BGLP program consists of a series of cross-sectional studies carried out collaboratively with states that are funded through ATSDR. The first BGLP Program (BGLP-I) began in 2010 and was completed in September 2015 through cooperative agreements with state health departments in Michigan, Minnesota, and New York. The three state programs targeted susceptible adult populations living in designated areas of contamination. Contaminants measured in all populations include mercury, lead, mirex, hexachlorobenzene, dichlorodiphenyltrichloroethane, and selected polychlorinated biphenyl congeners. In addition, some chemicals of emerging concern, such as per- and polyfluoroalkyl substances, were measured in several populations. The biomonitoring results helped guide public health actions to mitigate chemical exposures in these vulnerable Great Lakes populations. We provide an overview of the BGLP-I program's study populations, designs, and general methods. This overview provides a lead-in for subsequent manuscripts that present human biomonitoring data for legacy and emerging contaminants in culturally diverse susceptible populations—i.e., shoreline anglers, sport anglers, American Indians, and Burmese immigrants—residing in seven areas of concern.
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