Bisphenol A levels in human urine.

Bisphenol A levels in human urine.
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DOI:
10.1289/ehp.5512
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发表时间:
2003-01
影响因子:
10.4
通讯作者:
Kawamoto T
Kawamoto T
中科院分区:
环境科学与生态学1区
文献类型:
--
作者:
Matsumoto A;Kunugita N;Kitagawa K;Isse T;Oyama T;Foureman GL;Morita M;Kawamoto T

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双酚A(BPA)的雌激素效应已在人类细胞(E-screen测定)和啮齿动物体内(/斜体)研究中报告,尽管后一报告仍存在争议,BPA在人类中的暴露水平和不良健康影响也存在争议。在这项研究中,我们报告了一种分析高效液相色谱/荧光方法的BPA及其共轭物在人类尿液和应用这种方法在两个学生队列。尿液,沿着吸烟,饮酒,咖啡/茶消费的信息,收集在两个不同的年份从两个不同的大学生群体,50在1992年和56在1999年。整体而言,1992年学生的尿中BPA水平明显高于1999年。在1992年的队列中,BPA水平与咖啡和茶的消费量呈正相关,但在1999年的队列中则不然。我们推测,最近的变化,在日本有关内部涂层的罐用于包装这些饮料可能部分解释这些发现。
The estrogenic effects of bisphenol A (BPA) have been reported in human cells (E-screen assays) and in (italic)in vivo(/italic) studies of rodents, although the latter reports remain controversial, as do the exposure levels and adverse health effects of BPA in humans. In this study we report on an analytical high-performance liquid chromatography/fluorescence method for BPA and its conjugate in human urine and on the application of this method in two student cohorts. Urine, along with information on smoking, alcohol intake, and coffee/tea consumption, was collected in two different years from two different groups of university students, 50 in 1992 and 56 in 1999. Overall, the urinary BPA levels in the students in 1992 were significantly higher than were those in 1999. The BPA levels were also positively correlated with coffee and tea consumption in the 1992 cohort but not in the 1999 cohort. We speculate that recent changes made in Japan regarding the interior coating of cans used to package these beverages may partly explain these findings.
DOI: 10.2307/3432519
发表时间: 1995-10-01
影响因子: 10.4
作者:
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发表时间: 2001-07-01
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