The Contribution of Increased Gamma Band Connectivity to Visual Non-Verbal Reasoning in Autistic Children: A MEG Study.
The Contribution of Increased Gamma Band Connectivity to Visual Non-Verbal Reasoning in Autistic Children: A MEG Study.
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DOI：
10.1371/journal.pone.0163133
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发表时间：
2016
期刊：
影响因子：
3.7
通讯作者：
Minabe Y
中科院分区：
文献类型：
--
作者：
Takesaki N;Kikuchi M;Yoshimura Y;Hiraishi H;Hasegawa C;Kaneda R;Nakatani H;Takahashi T;Mottron L;Minabe Y
一些自闭症谱系（AS）患者在视觉推理任务上的表现比他们一般认知能力所预测的要好。在患有阿斯伯格综合症的个体中，大脑视觉区域中作为视觉处理基础的机制在视觉推理任务中扮演着比正常人更重要的角色。此外，与视觉区域的连接增加被认为是自闭症视觉认知能力的神经基础之一。然而，这种大脑连接对视觉认知能力的贡献尚未得到很好的理解，特别是在儿童中。在这项研究中，我们研究了典型发育（TD）儿童（n = 18）和AS儿童（n = 18）的视觉区域和高阶区域之间的功能连接如何影响视觉推理任务的表现，这是由α、β和γ波段振荡反映的。脑活动测量使用定制儿童大小的脑磁仪。想象相干分析被用作代理来估计枕部和大脑其他区域之间的功能连通性。来自枕区更强的连通性，正如伽马波段更高的想象相干性所证明的那样，只与as儿童的更高表现有关。我们观察到两组的α或β波段想象相干性和表现之间没有显著的相关性。α和β波段反映自上而下的途径，而γ波段振荡反映自下而上的影响。因此，我们的研究结果表明，AS儿童的视觉推理至少部分是基于对视觉感知的增强依赖和视觉区域自下而上连接的增加。
Some individuals with autism spectrum (AS) perform better on visual reasoning tasks than would be predicted by their general cognitive performance. In individuals with AS, mechanisms in the brain’s visual area that underlie visual processing play a more prominent role in visual reasoning tasks than they do in normal individuals. In addition, increased connectivity with the visual area is thought to be one of the neural bases of autistic visual cognitive abilities. However, the contribution of such brain connectivity to visual cognitive abilities is not well understood, particularly in children. In this study, we investigated how functional connectivity between the visual areas and higher-order regions, which is reflected by alpha, beta and gamma band oscillations, contributes to the performance of visual reasoning tasks in typically developing (TD) (n = 18) children and AS children (n = 18). Brain activity was measured using a custom child-sized magneto-encephalograph. Imaginary coherence analysis was used as a proxy to estimate the functional connectivity between the occipital and other areas of the brain. Stronger connectivity from the occipital area, as evidenced by higher imaginary coherence in the gamma band, was associated with higher performance in the AS children only. We observed no significant correlation between the alpha or beta bands imaginary coherence and performance in the both groups. Alpha and beta bands reflect top-down pathways, while gamma band oscillations reflect a bottom-up influence. Therefore, our results suggest that visual reasoning in AS children is at least partially based on an enhanced reliance on visual perception and increased bottom-up connectivity from the visual areas.
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影响因子：
16.2
作者：
Fries P
通讯作者：
Fries P
影响因子：
16.2
作者：
Bosman CA;Schoffelen JM;Brunet N;Oostenveld R;Bastos AM;Womelsdorf T;Rubehn B;Stieglitz T;De Weerd P;Fries P
通讯作者：
Fries P
自闭症儿童的定制磁脑摄影设备揭示了大脑连通性和高读数/解码能力。
影响因子：
4.6
作者：
Kikuchi, Mitsuru;Yoshimura, Yuko;Shitamichi, Kiyomi;Ueno, Sanae;Hirosawa, Tetsu;Munesue, Toshio;Ono, Yasuki;Tsubokawa, Tsunehisa;Haruta, Yasuhiro;Oi, Manabu;Niida, Yo;Remijn, Gerard B.;Takahashi, Tsutomu;Suzuki, Michio;Higashida, Haruhiro;Minabe, Yoshio
通讯作者：
Minabe, Yoshio
影响因子：
4.2
作者：
Kikuchi, Mitsuru;Shitamichi, Kiyomi;Yoshimura, Yuko;Ueno, Sanae;Hiraishi, Hirotoshi;Hirosawa, Tetsu;Munesue, Toshio;Nakatani, Hideo;Tsubokawa, Tsunehisa;Haruta, Yasuhiro;Oi, Manabu;Niida, Yo;Remijn, Gerard B.;Takahashi, Tsutomu;Suzuki, Michio;Higashida, Haruhiro;Minabe, Yoshio
通讯作者：
Minabe, Yoshio
影响因子：
5.7
作者：
Doesburg, Sam M.;Bedo, Nicolas;Ward, Lawrence M.
通讯作者：
Ward, Lawrence M.