Altered brain connectivity in 3-to 7-year-old children with autism spectrum disorder.
Altered brain connectivity in 3-to 7-year-old children with autism spectrum disorder.
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DOI：
10.1016/j.nicl.2013.03.003
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发表时间：
2013
影响因子：
4.2
通讯作者：
Minabe, Yoshio
中科院分区：
文献类型：
--
作者：
Kikuchi, Mitsuru;Shitamichi, Kiyomi;Yoshimura, Yuko;Ueno, Sanae;Hiraishi, Hirotoshi;Hirosawa, Tetsu;Munesue, Toshio;Nakatani, Hideo;Tsubokawa, Tsunehisa;Haruta, Yasuhiro;Oi, Manabu;Niida, Yo;Remijn, Gerard B.;Takahashi, Tsutomu;Suzuki, Michio;Higashida, Haruhiro;Minabe, Yoshio
关键词：
自闭症谱系障碍(ASD)通常被描述为异常的神经连接和/或异常的半球偏侧的障碍。尽管研究ASD皮质发育的病理生理学很重要，但ASD儿童大脑在意识状态下的生理连通性尚未被描述。脑磁图(MEG)是一种非侵入性的脑成像技术，适用于幼儿。脑磁图产生一个无参照物的信号，因此是计算两个遥远的大脑皮层节律之间的一致性的理想工具。使用定制的儿童大小的脑磁图，我们最近报告说，患有自闭症的5至7岁儿童(n=26)与典型的发育中(TD)儿童具有天生不同的神经路径，这些神经路径有助于他们相对保留的视觉任务表现。在这项研究中，我们对70名幼儿(3-7岁，其中18名3-4岁)进行了无创性脑活动测量，样本包括35名ASD儿童和35名TD儿童。使用9个频段的大脑半球内一致性来评估生理连通性和生理连通性的偏侧性。结果发现，在ASD组中，通过伽马频段振荡，顶颞区之间存在显著的向右连接。由于我们使用定制的儿童大小的脑磁图获得了非侵入性测量，这是第一项在患有ASD的清醒幼儿(包括3-4岁儿童)中展示向右偏侧的神经生理网络的研究。一种定制的儿童大小的脑磁图系统被用于幼儿。在自闭症谱系障碍中观察到向右的大脑半球内连接。在自闭症谱系障碍患者中观察到通过伽马频段的向右连接。
Autism spectrum disorder (ASD) is often described as a disorder of aberrant neural connectivity and/or aberrant hemispheric lateralization. Although it is important to study the pathophysiology of the developing ASD cortex, the physiological connectivity of the brain in young children with ASD under conscious conditions has not yet been described. Magnetoencephalography (MEG) is a noninvasive brain imaging technique that is practical for use in young children. MEG produces a reference-free signal and is, therefore, an ideal tool for computing the coherence between two distant cortical rhythms. Using a custom child-sized MEG, we recently reported that 5- to 7-year-old children with ASD (n = 26) have inherently different neural pathways than typically developing (TD) children that contribute to their relatively preserved performance of visual tasks. In this study, we performed non-invasive measurements of the brain activity of 70 young children (3–7 years old, of which 18 were aged 3-4 years), a sample consisting of 35 ASD children and 35 TD children. Physiological connectivity and the laterality of physiological connectivity were assessed using intrahemispheric coherence for 9 frequency bands. As a result, significant rightward connectivity between the parietotemporal areas, via gamma band oscillations, was found in the ASD group. As we obtained the non-invasive measurements using a custom child-sized MEG, this is the first study to demonstrate a rightward-lateralized neurophysiological network in conscious young children (including children aged 3–4 years) with ASD. A custom child-sized magnetoencephalography system was used for young children. Rightward intrahemispheric connectivity was observed in autism spectrum disorder. Rightward connectivity via gamma band was observed in autism spectrum disorder.
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自闭症儿童的定制磁脑摄影设备揭示了大脑连通性和高读数/解码能力。
影响因子：
4.6
作者：
Kikuchi, Mitsuru;Yoshimura, Yuko;Shitamichi, Kiyomi;Ueno, Sanae;Hirosawa, Tetsu;Munesue, Toshio;Ono, Yasuki;Tsubokawa, Tsunehisa;Haruta, Yasuhiro;Oi, Manabu;Niida, Yo;Remijn, Gerard B.;Takahashi, Tsutomu;Suzuki, Michio;Higashida, Haruhiro;Minabe, Yoshio
通讯作者：
Minabe, Yoshio
DOI：
10.1126/science.1171402
发表时间：
2009-05-29
期刊：
Science (New York, N.Y.)
影响因子：
--
作者：
Gregoriou GG;Gotts SJ;Zhou H;Desimone R
通讯作者：
Desimone R
影响因子：
1.7
作者：
Grice, SJ;Spratling, MW;Johnson, MH
通讯作者：
Johnson, MH
影响因子：
14.5
作者：
Just, MA;Cherkassky, VL;Minshew, NJ
通讯作者：
Minshew, NJ
影响因子：
1.7
作者：
Kikuchi, Mitsuru;Shitamichi, Kiyomi;Minabe, Yoshio
通讯作者：
Minabe, Yoshio