Prenatal depression and anxiety in Toxoplasma gondii-positive women.
Prenatal depression and anxiety in Toxoplasma gondii-positive women.
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DOI：
10.1016/j.ajog.2011.01.004
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发表时间：
2011-05
影响因子：
9.8
通讯作者：
Postolache TT
中科院分区：
文献类型：
--
作者：
Groër MW;Yolken RH;Xiao JC;Beckstead JW;Fuchs D;Mohapatra SS;Seyfang A;Postolache TT
本研究分析了孕妇产前情绪状态与弓形虫免疫应答的关系。第二个目的是确定甲状腺过氧化物酶（TPO）自身抗体状态是否与弓形虫状态相关。妊娠16至25周的孕妇（N=414）进行了人口统计学和情绪问卷调查和抽血。分析所有血浆样品的TPO和T。弓形虫IgG、色氨酸、犬尿氨酸和新蝶呤。细胞因子在一个子集（N=142）上可用。有血清学证据表明接触T。44例弓形虫感染者血清IgG水平与POMS抑郁、焦虑分量表呈正相关。T.血浆TNF-α较高。弓形虫阳性的女性高T。感染孕妇的弓形虫IgG滴度与妊娠期焦虑和抑郁有关。弓形虫的重新激活或对弓形虫的免疫反应可能会改变孕妇的情绪。
This study analyzed relationship between prenatal mood states and serological evidence of immune response to Toxoplasma gondii (T.gondii). A secondary aim was to determine if thyroid peroxidase (TPO) autoantibody status was related to T.gondii status. Pregnant women (N=414) were measured between 16 to 25 weeks gestation with demographic and mood questionnaires and a blood draw. All plasma samples were analyzed for TPO and T. gondii IgG, tryptophan, kynurenine and neopterin. Cytokines were available on a subset (N=142). Women with serological evidence of exposure to T. gondii (N=44) showed positive correlations between IgG levels, and the Profile of Mood Scales (POMS) depression and anxiety subscales. Plasma TNF-α was higher in T. gondii positive women. Higher T. gondii IgG titers in infected women were related to anxiety and depression during pregnancy. Reactivation of T.gondii or immune responses to T.gondii may alter mood in pregnant women.
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影响因子：
2.7
作者：
Gonzalez, Luis E.;Rojnik, Belen;Hernandez, Luis
通讯作者：
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影响因子：
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作者：
Kohl, C;Walch, T;Sperner-Unterweger, B
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DOI：
10.1111/j.1471-0528.2004.00302.x
发表时间：
2005-02-01
影响因子：
5.8
作者：
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通讯作者：
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影响因子：
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作者：
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