Microvascular guidance: a challenge to support the development of vascularised tissue engineering construct.
Microvascular guidance: a challenge to support the development of vascularised tissue engineering construct.
复制标题
DOI：
10.1100/2012/201352
复制
发表时间：
2012
影响因子：
--
通讯作者：
Sukmana I
中科院分区：
文献类型：
--
作者：
Sukmana I
引导内皮细胞组织形成毛细血管网络一直是组织工程学中的一个长期挑战。已经做出了一些研究努力来开发方法来促进工程化组织结构内的毛细血管网络。可以模拟血管微血管功能的毛细血管和血管网络随后可用于促进氧气和营养物质的转移以及废物的清除。血管化的工程化组织结构是克服营养和氧气供应限制的最有利策略之一，而营养和氧气供应限制往往是发展厚而复杂的组织和人工器官的主要障碍。本文介绍了三维培养系统发展的最新进展和未来的挑战，以促进组织构建血管形成，从而模拟体内遇到的血管微血管的发育和功能。还将概述用于创建完全血管化的功能组织结构的生物反应器系统。
The guidance of endothelial cell organization into a capillary network has been a long-standing challenge in tissue engineering. Some research efforts have been made to develop methods to promote capillary networks inside engineered tissue constructs. Capillary and vascular networks that would mimic blood microvessel function can be used to subsequently facilitate oxygen and nutrient transfer as well as waste removal. Vascularization of engineering tissue construct is one of the most favorable strategies to overpass nutrient and oxygen supply limitation, which is often the major hurdle in developing thick and complex tissue and artificial organ. This paper addresses recent advances and future challenges in developing three-dimensional culture systems to promote tissue construct vascularization allowing mimicking blood microvessel development and function encountered in vivo. Bioreactors systems that have been used to create fully vascularized functional tissue constructs will also be outlined.
登录
查看更多内容
影响因子：
14.5
作者：
Ahmad, SA;Jung, YD;Ellis, LM
通讯作者：
Ellis, LM
影响因子：
2.9
作者：
DUBAND, JL;GIMONA, M;SMALL, JV
通讯作者：
SMALL, JV
影响因子：
3.8
作者：
BELFORT, G
通讯作者：
BELFORT, G
影响因子：
14
作者：
Almany, L;Seliktar, D
通讯作者：
Seliktar, D
影响因子：
3.1
作者：
Arthur, WT;Vernon, RB;Reed, MJ
通讯作者：
Reed, MJ