Sex-specific neurotoxic effects of early-life exposure to fluoride: A review of the epidemiologic and animal literature.
Sex-specific neurotoxic effects of early-life exposure to fluoride: A review of the epidemiologic and animal literature.
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DOI：
10.1007/s40471-020-00246-1
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发表时间：
2020-12
影响因子：
3.3
通讯作者：
Till C
中科院分区：
文献类型：
--
作者：
Green R;Rubenstein J;Popoli R;Capulong R;Till C
越来越多的证据表明，生命早期接触氟化物对神经发育的不利影响可能因接触时间和接触者的性别而异。我们进行了文献检索，以确定动物和人类流行病学研究，这些研究检查了性别特异性神经发育差异对产前和产后氟化物暴露的反应。138项动物研究中的6项和106项人类流行病学研究中的15项测试了性别特异性影响。在六项动物研究中，有四项发现产前接触氟化物与男性易受不良行为影响有关，在三项前瞻性队列研究中，有一项发现男性智商较低。检验与出生后氟化物接触有关的性别影响的证据很少，而且许多动物和横断面人体研究被认为具有很高的偏倚风险。与雌性相比，雄性后代似乎对产前接触氟化物更敏感，但对产后接触氟化物则不敏感。我们讨论了几种性别特异性机制，并强调了未来研究的必要性。
A growing body of evidence suggests adverse neurodevelopmental effects of early-life exposure to fluoride that may differ depending on timing of exposure and sex of the exposed. We conducted a literature search to identify the animal and human epidemiologic studies that examined sex-specific neurodevelopmental differences in response to prenatal and postnatal exposure to fluoride. Six of 138 animal studies and 15 of 106 human epidemiologic studies tested for sex-specific effects. Prenatal exposure to fluoride was associated with a male susceptibility to adverse behavioural effects in four of six animal studies and lower IQ in one of three prospective cohort studies. The body of evidence examining sex-effects associated with postnatal fluoride exposure was scarce, and many animal and cross-sectional human studies were considered to have a high risk of bias. Compared to females, male offspring appear to be more sensitive to prenatal, but not postnatal, exposure to fluoride. We discuss several sex-specific mechanisms and emphasize the need for future research.
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