The potential role of vitamin D supplementation as a gut microbiota modifier in healthy individuals.
The potential role of vitamin D supplementation as a gut microbiota modifier in healthy individuals.
复制标题
维生素D补充剂作为健康个体肠道微生物群调节剂的潜在作用。
DOI：
10.1038/s41598-020-77806-4
复制
发表时间：
2020-12-10
影响因子：
4.6
通讯作者：
Al Khodor S
中科院分区：
文献类型：
--
作者：
Singh P;Rawat A;Alwakeel M;Sharif E;Al Khodor S
在一些国家，维生素D缺乏症影响着大约80%的人，并与肠道生态失调和炎症有关。虽然维生素D补充剂对肠道微生物群的益处已经在慢性疾病患者中进行了研究，但其对其他健康个体微生物群的影响尚不清楚。此外，对微生物群的影响是否可以解释对维生素D补充的反应性的一些显着个体间差异尚不清楚。在这里，我们向80名健康的维生素D缺乏女性给予维生素D，测量血液中的血清25（OH）D水平，并使用16S rRNA基因测序来表征补充前后的肠道微生物群。补充维生素D显著增加肠道微生物多样性。具体而言，拟杆菌与厚壁菌的比例随着促进健康的益生菌分类群阿克曼氏菌和双歧杆菌的丰度而沿着增加。两个优势属，拟杆菌属和普雷沃菌属的显着变化，表明补充后肠型的变化。比较补充剂应答者和无应答者，我们发现应答者中主要门的丰度变化更明显，无应答者中产酸拟杆菌显著减少。总之，我们的研究强调了维生素D补充剂对肠道微生物群的积极影响，以及微生物肠道特征影响维生素D反应的潜力。
Vitamin D deficiency affects approximately 80% of individuals in some countries and has been linked with gut dysbiosis and inflammation. While the benefits of vitamin D supplementation on the gut microbiota have been studied in patients with chronic diseases, its effects on the microbiota of otherwise healthy individuals is unclear. Moreover, whether effects on the microbiota can explain some of the marked inter-individual variation in responsiveness to vitamin D supplementation is unknown. Here, we administered vitamin D to 80 otherwise healthy vitamin D-deficient women, measuring serum 25(OH) D levels in blood and characterizing their gut microbiota pre- and post- supplementation using 16S rRNA gene sequencing. Vitamin D supplementation significantly increased gut microbial diversity. Specifically, the Bacteroidetes to Firmicutes ratio increased, along with the abundance of the health-promoting probiotic taxa Akkermansia and Bifidobacterium. Significant variations in the two-dominant genera, Bacteroides and Prevotella, indicated a variation in enterotypes following supplementation. Comparing supplementation responders and non-responders we found more pronounced changes in abundance of major phyla in responders, and a significant decrease in Bacteroides acidifaciens in non-responders. Altogether, our study highlights the positive impact of vitamin D supplementation on the gut microbiota and the potential for the microbial gut signature to affect vitamin D response.
登录
查看更多内容
影响因子：
48
作者：
Callahan BJ;McMurdie PJ;Rosen MJ;Han AW;Johnson AJ;Holmes SP
通讯作者：
Holmes SP
影响因子：
64.8
作者：
Arumugam, Manimozhiyan;Raes, Jeroen;Pelletier, Eric;Le Paslier, Denis;Yamada, Takuji;Mende, Daniel R.;Fernandes, Gabriel R.;Tap, Julien;Bruls, Thomas;Batto, Jean-Michel;Bertalan, Marcelo;Borruel, Natalia;Casellas, Francesc;Fernandez, Leyden;Gautier, Laurent;Hansen, Torben;Hattori, Masahira;Hayashi, Tetsuya;Kleerebezem, Michiel;Kurokawa, Ken;Leclerc, Marion;Levenez, Florence;Manichanh, Chaysavanh;Nielsen, H. Bjorn;Nielsen, Trine;Pons, Nicolas;Poulain, Julie;Qin, Junjie;Sicheritz-Ponten, Thomas;Tims, Sebastian;Torrents, David;Ugarte, Edgardo;Zoetendal, Erwin G.;Wang, Jun;Guarner, Francisco;Pedersen, Oluf;de Vos, Willem M.;Brunak, Soren;Dore, Joel;Weissenbach, Jean;Ehrlich, S. Dusko;Bork, Peer
通讯作者：
Bork, Peer
DOI：
10.1016/j.jsbmb.2016.12.011
发表时间：
2018-01-01
影响因子：
4.1
作者：
Carlberg, Carsten;Haq, Afrozul
通讯作者：
Haq, Afrozul
DOI：
10.3945/ajcn.115.120873
发表时间：
2016-04
期刊：
The American journal of clinical nutrition
影响因子：
--
作者：
Cashman KD;Dowling KG;Škrabáková Z;Gonzalez-Gross M;Valtueña J;De Henauw S;Moreno L;Damsgaard CT;Michaelsen KF;Mølgaard C;Jorde R;Grimnes G;Moschonis G;Mavrogianni C;Manios Y;Thamm M;Mensink GB;Rabenberg M;Busch MA;Cox L;Meadows S;Goldberg G;Prentice A;Dekker JM;Nijpels G;Pilz S;Swart KM;van Schoor NM;Lips P;Eiriksdottir G;Gudnason V;Cotch MF;Koskinen S;Lamberg-Allardt C;Durazo-Arvizu RA;Sempos CT;Kiely M
通讯作者：
Kiely M
影响因子：
4
作者：
D'Aimmo, M. R.;Mattarelli, P.;Andlid, T.
通讯作者：
Andlid, T.