Lysogenic Streptococcus suis isolate SS2-4 containing prophage SMP showed increased mortality in zebra fish compared to the wild-type isolate.

Lysogenic Streptococcus suis isolate SS2-4 containing prophage SMP showed increased mortality in zebra fish compared to the wild-type isolate.
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DOI:
10.1371/journal.pone.0054227
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发表时间:
2013
期刊:
影响因子:
3.7
通讯作者:
Lu C
Lu C
中科院分区:
综合性期刊3区
文献类型:
--
作者:
Tang F;Zhang W;Lu C

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猪链球菌(Streptococcus suis,S.猪感染被认为是全世界养猪业的主要问题。以荚膜型为基础,共分离到33个血清型。已经描述了猪,其中血清型2(SS 2)是最常从患病仔猪分离的。然而,关于S.猪。噬菌体的研究是沙门氏菌的一个新领域。suis研究。色葡萄猪血清2型噬菌体,命名为SMP,以前已在我们的实验室分离。在这里,我们选择了一个溶源性分离物,其中SMP噬菌体整合到菌株SS 2 -4的染色体中。与野生型分离株相比,溶原性菌株在斑马鱼中显示出增加的死亡率。此外,溶原性菌株对溶菌酶的敏感性是野生型的7倍。
Streptococcus suis (S. suis) infection is considered to be a major problem in the swine industry worldwide. Based on the capsular type, 33 serotypes of S. suis have been described, with serotype 2 (SS2) being the most frequently isolated from diseased piglets. Little is known, however, about the pathogenesis and virulence factors of S. suis. Research on bacteriophages highlights a new area in S. suis research. A S. suis serotype 2 bacteriophage, designated SMP, has been previously isolated in our laboratory. Here, we selected a lysogenic isolate in which the SMP phage was integrated into the chromosome of strain SS2-4. Compared to the wild-type isolate, the lysogenic strain showed increased mortality in zebra fish. Moreover the sensitivity of the lysogenic strain to lysozyme was seven times higher than that of the wild-type.
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