Smoking Cessation and Time Course of Decreased Risks of Coronary Heart Disease in Middle-Aged Women
Smoking Cessation and Time Course of Decreased Risks of Coronary Heart Disease in Middle-Aged Women
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中年女性戒烟及降低冠心病风险的时间进程
DOI：
10.1001/archinte.1994.00420020075009
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发表时间：
1994
影响因子：
39
通讯作者：
C. Hennekens
中科院分区：
文献类型：
--
作者：
I. Kawachi;G. Colditz;J. Stampfer;W. Willett;J. Manson;B. Rosner;F. Speizer;C. Hennekens
背景：我们前瞻性地研究了中年女性戒烟时间与冠心病风险的关系。研究方法：这项研究是基于护士健康研究的12年随访数据（1976年至1988年），这是一项正在进行的前瞻性队列研究，其中吸烟习惯的信息每两年通过邮寄问卷更新一次。研究人群包括117006名女性注册护士，年龄在1976年的30至55岁之间，基线时无冠心病、中风和癌症。所用的结局指标是冠心病事件，定义为非致死性心肌梗死加致死性冠心病。结果如下：在137万人年的随访期间，共有970例冠心病事件（215例从不吸烟的参与者，214例既往吸烟者，541例当前吸烟者）发生。与从不吸烟的参与者相比，目前吸烟者总冠心病的多变量相对风险为4.23（95%置信区间，3.60至4.96）。在15岁之前开始吸烟的吸烟者中，冠心病的风险最高（相对风险，9.25; 95%置信区间，5.27至16.23）。既往吸烟者的相对危险度为1.48（95%置信区间为1.22 ~ 1.79）。戒烟后，三分之一的冠心病风险在戒烟后2年内消除。此后，超额风险恢复到那些在戒烟后10至14年期间从未吸烟的人的水平。结论：戒烟的女性将立即受益，并将冠心病的额外风险进一步降低到从未吸烟的水平。(Arch 1994;154：169-175）
Background: We examined prospectively the relation of time since stopping smoking with risk of coronary heart disease in middle-aged women. Methods: The study was based on 12 years' follow-up data (1976 through 1988) from the Nurses' Health Study, an ongoing prospective cohort study, in which information on smoking habits was updated every 2 years by a mailed questionnaire. The study population consisted of 117 006 female registered nurses aged 30 to 55 years in 1976 who were free of coronary heart disease, stroke, and cancer at baseline. The outcome measure used was incident coronary heart disease, defined as nonfatal myocardial infarction plus fatal coronary heart disease. Results: A total of 970 incident cases of coronary heart disease (215 among participants who never smoked, 214 among former smokers, and 541 among current smokers) occurred during 1.37 million person-years of follow-up. The multivariate relative risk of total coronary heart disease among current smokers compared with participants who never smoked was 4.23(95% confidence interval, 3.60 to 4.96). Risk of coronary heart disease was highest among smokers who started smoking before the age of 15 years (relativerisk, 9.25; 95% confidence interval, 5.27 to 16.23). The relative risk among former smokers was 1.48 (95% confidence interval, 1.22 to 1.79). On stopping smoking, one third of the excess risk of coronary heart disease was eliminated within 2 years of cessation. Thereafter, the excess risk returned to the level of those who never smoked during the interval 10 to 14 years following cessation. Conclusion: Women who stop smoking will experience an immediate benefit as well as a further longerterm decline in excess risk of coronary heart disease to the level of those who never smoked. (Arch Intern Med. 1994;154:169-175)
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影响因子：
158.5
作者：
COLDITZ, GA;BONITA, R;HENNEKENS, CH
通讯作者：
HENNEKENS, CH
影响因子：
158.5
作者：
STAMPFER, MJ;WILLETT, WC;HENNEKENS, CH
通讯作者：
HENNEKENS, CH
影响因子：
5
作者：
Edward Glovannucci;G. Colditz;M. Stampfer;E. Rimm;L. Litin;L. Sampson;W. Willett
通讯作者：
Edward Glovannucci;G. Colditz;M. Stampfer;E. Rimm;L. Litin;L. Sampson;W. Willett
DOI：
10.1001/jama.1993.03500020066033
发表时间：
1993-01
期刊：
JAMA
影响因子：
--
作者：
Ichiro Kawachi;G. Colditz;M. Stampfer;W. Willett;J. Manson;B. Rosner;F. Speizer;C. Hennekens
通讯作者：
Ichiro Kawachi;G. Colditz;M. Stampfer;W. Willett;J. Manson;B. Rosner;F. Speizer;C. Hennekens
DOI：
10.1001/jama.1988.03720070025028
发表时间：
1988-02
期刊：
JAMA
影响因子：
--
作者：
P. Wolf;R. D’Agostino;W. Kannel;R. Bonita;A. Belanger
通讯作者：
P. Wolf;R. D’Agostino;W. Kannel;R. Bonita;A. Belanger