Network analysis: applications for the developing brain.

Network analysis: applications for the developing brain.
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DOI:
10.1177/0883073810385345
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发表时间:
2011-04
影响因子:
1.9
通讯作者:
Cash SS
Cash SS
中科院分区:
医学4区
文献类型:
--
作者:
Chu-Shore CJ;Kramer MA;Bianchi MT;Caviness VS;Cash SS

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人类大脑的发育遵循一个复杂的轨迹,即特定年龄的解剖学和生理学变化。网络分析的应用提供了一个启发性的视角,这个错综复杂的系统的动态区域间和全球属性。在这里,我们提供了一个关键的网络分析方法的概要,重点是开发大脑网络。在讨论了网络分析的基本概念和方法后,我们探讨了从妊娠期到青春期解剖皮质发育的主要事件。在这个框架下,我们描述了早期的工作,揭示了正常神经发育中年龄特异性功能脑网络的演变。最后,我们回顾这些关系如何在疾病中改变,甚至可能通过治疗来纠正。虽然这种描述和探究的方法仍然处于早期形式,但已经有大量证据表明,应用网络模型和分析来理解正常和异常的人类神经发育对未来的发现具有巨大的希望。
Development of the human brain follows a complex trajectory of age-specific anatomical and physiological changes. The application of network analysis provides an illuminating perspective on the dynamic interregional and global properties of this intricate and complex system. Here, we provide a critical synopsis of methods of network analysis with a focus on developing brain networks. After discussing basic concepts and approaches to network analysis, we explore the primary events of anatomical cortical development from gestation through adolescence. Upon this framework, we describe early work revealing the evolution of age-specific functional brain networks in normal neurodevelopment. Finally, we review how these relationships can be altered in disease and perhaps even rectified with treatment. While this method of description and inquiry remains in early form, there is already substantial evidence that the application of network models and analysis to understanding normal and abnormal human neural development holds tremendous promise for future discovery.
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