Modular deconstruction reveals the dynamical and physical building blocks of a locomotion motor program.
Modular deconstruction reveals the dynamical and physical building blocks of a locomotion motor program.
复制标题
模块化解构揭示了运动电机程序的动态和物理构建块。
DOI:
10.1016/j.neuron.2015.03.005
复制
发表时间:
2015-04-08
期刊:
影响因子:
16.2
通讯作者:
Humphries MD
中科院分区:
文献类型:
--
作者:
Bruno AM;Frost WN;Humphries MD
The neural substrates of motor programs are only well understood for small, dedicated circuits. Here we investigate how a motor program is constructed within a large network. We imaged populations of neurons in the Aplysia pedal ganglion during execution of a locomotion motor program. We found that the program was built from a very small number of dynamical building blocks, including both neural ensembles and low-dimensional rotational dynamics. These map onto physically discrete regions of the ganglion, so that the motor program has a corresponding modular organization in both dynamical and physical space. Using this dynamic map, we identify the population potentially implementing the rhythmic pattern generator and find that its activity physically traces a looped trajectory, recapitulating its low-dimensional rotational dynamics. Our results suggest that, even in simple invertebrates, neural motor programs are implemented by large, distributed networks containing multiple dynamical systems.
登录
查看更多内容
影响因子:
64.8
作者:
通讯作者:
--
影响因子:
3.7
作者:
Hill ES;Vasireddi SK;Bruno AM;Wang J;Frost WN
通讯作者:
Frost WN
影响因子:
2.5
作者:
Compte, A;Constantinidis, C;Wang, WJ
通讯作者:
Wang, WJ
DOI:
10.1007/s003590000117
发表时间:
2000-07-01
影响因子:
2.1
作者:
Eisenhart, FJ;Cacciatore, TW;Kristan, WB
通讯作者:
Kristan, WB
影响因子:
3.8
作者:
FREDMAN, SM;JAHANPARWAR, B
通讯作者:
JAHANPARWAR, B