Pesticide exposure and child growth in low- and middle-income countries: A systematic review.
Pesticide exposure and child growth in low- and middle-income countries: A systematic review.
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DOI：
10.1016/j.envres.2022.114230
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发表时间：
2022-12
影响因子：
8.3
通讯作者：
Jaacks LM
中科院分区：
文献类型：
--
作者：
Bliznashka L;Roy A;Jaacks LM
在低收入和中等收入国家，农药被广泛用于农业和住宅环境。人们对杀虫剂如何影响儿童生长知之甚少。系统地审查和综合低收入国家中农药接触与不良出生结果和/或5岁以下儿童出生后发育受损之间关系的证据。我们检索了从成立到2021年11月的10个数据库。我们纳入了队列和横断面研究，调查自我报告或测量的产前或产后农药暴露与儿童生长（产后儿童线性/体重生长和/或出生结局）之间的关联。两名研究人员筛选研究，提取数据，并使用GRADE评估确定性。该方案已在PROSPERO（CRD 42021292919）进行了预注册。在检索到的939份记录中，31项研究符合纳入标准（11项队列研究，20项横断面研究）。所有研究均评估了产前暴露。24项研究报告了出生体重。四个发现与有机氯（0.01-0.25标准化平均差异（SMD））和两个发现负相关（-0.009 SMD至-55克）。还记录了与有机磷（-170 g，n = 1）和拟除虫菊酯（-97至-233 g，n = 2）的负相关性。在15项报告出生长度的研究中，有两项发现与有机氯存在正相关（0.21-0.25 SMD），一项发现与有机氯存在负相关（-0.25至-0.32 SMD）。有机磷暴露与出生身长呈负相关（-0.37 cm，n = 1）。有机磷暴露还与低出生体重（9项研究中的2项）和早产（6项研究中的2项）的风险/患病率较高相关。所有结局的证据可靠性均为“非常低”。来自中低收入国家的有限文献显示，产前农药暴露、儿童生长和出生结局之间存在不确定的关联。为了更好地了解农药如何影响儿童生长，需要在可比人群中使用一致的方法对低收入国家常用农药暴露情况进行准确的定量数据研究。
In low- and middle-income countries (LMICs), pesticides are widely used in agricultural and residential settings. Little is known about how pesticides affect child growth. To systematically review and synthesise the evidence on the associations between pesticide exposure and adverse birth outcomes and/or impaired postnatal growth in children up to 5 years of age in LMICs. We searched 10 databases from inception through November 2021. We included cohort and cross-sectional studies investigating associations between self-reported or measured prenatal or postnatal pesticide exposure and child growth (postnatal child linear/ponderal growth, and/or birth outcomes). Two researchers screened studies, extracted data, and assessed certainty using GRADE. The protocol was preregistered with PROSPERO (CRD42021292919). Of 939 records retrieved, 31 studies met inclusion criteria (11 cohort, 20 cross-sectional). All studies assessed prenatal exposure. Twenty-four studies reported on birth weight. Four found positive associations with organochlorines (0.01–0.25 standardised mean difference (SMD)) and two found negative associations (–0.009 SMD to –55 g). Negative associations with organophosphates (–170 g, n = 1) and pyrethroids (–97 to –233 g, n = 2) were also documented. Two (out of 15) studies reporting on birth length found positive associations with organochlorines (0.21–0.25 SMD) and one found negative associations (–0.25 to –0.32 SMD). Organophosphate exposure was negatively associated with birth length (–0.37 cm, n = 1). Organophosphate exposure was also associated with higher risk/prevalence of low birth weight (2 out of nine studies) and preterm birth (2 out of six studies). Certainty of the evidence was “very low” for all outcomes. The limited literature from LMICs shows inconclusive associations between prenatal pesticide exposure, child growth, and birth outcomes. Studies with accurate quantitative data on exposure to commonly used pesticides in LMICs using consistent methodologies in comparable populations are needed to better understand how pesticides influence child growth.
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影响因子：
10.4
作者：
Eskenazi B;Harley K;Bradman A;Weltzien E;Jewell NP;Barr DB;Furlong CE;Holland NT
通讯作者：
Holland NT
影响因子：
6
作者：
Donley, Nathan
通讯作者：
Donley, Nathan
影响因子：
8.3
作者：
Debost-Legrand, Anne;Warembourg, Charline;Cordier, Sylvaine
通讯作者：
Cordier, Sylvaine
影响因子：
11.8
作者：
Coker E;Chevrier J;Rauch S;Bradman A;Obida M;Crause M;Bornman R;Eskenazi B
通讯作者：
Eskenazi B
影响因子：
8.3
作者：
Balalian AA;Liu X;Herbstman JB;Daniel S;Whyatt R;Rauh V;Calafat AM;Wapner R;Factor-Litvak P
通讯作者：
Factor-Litvak P