Cortical and subcortical changes in typically developing preadolescent children.
Cortical and subcortical changes in typically developing preadolescent children.
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DOI：
10.1016/j.brainres.2011.05.018
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发表时间：
2011-07-05
期刊：
影响因子：
2.9
通讯作者：
Sandman CA
中科院分区：
文献类型：
--
作者：
Muftuler LT;Davis EP;Buss C;Head K;Hasso AN;Sandman CA
有证据表明，儿童时期大脑发育异常是各种认知和精神疾病的危险因素。然而，对于典型发育儿童的大样本，特别是在狭窄的青春期前年龄范围内，没有足够的规范数据。我们分析了 126 名 6 至 10 岁正常发育儿童的高分辨率 MRI 图像。评估了与年龄相关的皮质厚度和主要皮质下结构体积的差异。随着年龄的增长，枕叶、顶叶和体感区域以及颞叶和额叶的不同区域的皮质变薄。在本研究分析的主要皮质下结构中，在考虑颅内容量后，只有丘脑显示出随着年龄的增长，体积增加。在研究的年龄范围内，男孩和女孩与年龄相关的皮质和皮质下差异相似，但右侧岛叶除外，女孩的右侧岛叶厚度随年龄略有增加。研究结果揭示了与年龄相关的大脑解剖学变化，提供了有关儿童晚期正常大脑发育轨迹的信息。
There is evidence that abnormal cerebral development during childhood is a risk factor for various cognitive and psychiatric disorders. There is not, however, sufficient normative data available on large samples of typically developing children, especially within the narrow preadolescent age range. We analyzed high resolution MRI images from 126 normally developing children between ages 6 and 10 years. Age related differences in cortical thickness and in the volumes of major subcortical structures were assessed. Thinner cortices were observed in the occipital, parietal and somatosensory regions as well as in distinct regions of the temporal and frontal lobes with increasing age. Among the major subcortical sructures analyzed in this study, only the thalamus showed increased volume with age after accounting for intracranial volume. Within the age range studied age-related cortical and subcortical differences were similar for boys and girls except for the right insula, where girls showed slight increase in thickness with age. The findings reveal age-associated changes in brain anatomy, providing information about the trajectory of normal brain development during late childhood.
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DOI：
10.1073/pnas.0402680101
发表时间：
2004-05-25
影响因子：
11.1
作者：
Gogtay, N;Giedd, JN;Thompson, PM
通讯作者：
Thompson, PM
影响因子：
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作者：
Fischl, B;Sereno, MI;Dale, AM
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Dale, AM
DOI：
10.1152/ajpregu.00084.2006
发表时间：
2006-08-01
影响因子：
2.8
作者：
Moulton, Eric A.;Keaser, Michael L.;Greenspan, Joel D.
通讯作者：
Greenspan, Joel D.
影响因子：
5.7
作者：
Dale, AM;Fischl, B;Sereno, MI
通讯作者：
Sereno, MI
影响因子：
8.2
作者：
Andersen, SL
通讯作者：
Andersen, SL