Hippocampus and amygdala fear memory engrams re-emerge after contextual fear relapse
Hippocampus and amygdala fear memory engrams re-emerge after contextual fear relapse
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情境恐惧复发后，海马和杏仁核恐惧记忆印记重新出现
作者：
Yosif Zaki;W. Mau;C. Cincotta;Amy Monasterio;Emma Odom;Emily Doucette;Stephanie L. Grella;Emily B. Merfeld;Monika Shpokayte;S. Ramirez
恐惧记忆的形成和消失代表了两种形式的学习，每种学习都涉及海马体和杏仁核。然而，这些区域的细胞群如何导致恐惧复发仍不清楚。在这里，我们证明，在雄性小鼠中，海马齿状回的恐惧条件反射过程中活跃的细胞在灭绝过程中表现出活动减少，并在上下文恐惧复发后重新参与。体内钙离子成像显示，复发驱动基底外侧杏仁核中的群体动力学恢复到与恐惧条件反射期间存在的状态类似的网络状态。最后，我们发现，在海马体或杏仁核中的恐惧条件反射期间活跃的神经元集合的光遗传学失活足以破坏复发后的恐惧表达，而在消退后这些相同集合的光遗传学刺激不足以人工模拟恐惧复发。这些结果表明，恐惧复发触发了原始恐惧记忆表征的部分再现，为恐惧复发的神经基质提供了新的见解。
The formation and extinction of fear memories represent two forms of learning that each engage the hippocampus and amygdala. How cell populations in these areas contribute to fear relapse, however, remains unclear. Here, we demonstrate that, in male mice, cells active during fear conditioning in the dentate gyrus of hippocampus exhibit decreased activity during extinction and are re-engaged after contextual fear relapse. In vivo calcium imaging reveals that relapse drives population dynamics in the basolateral amygdala to revert to a network state similar to the state present during fear conditioning. Finally, we find that optogenetic inactivation of neuronal ensembles active during fear conditioning in either the hippocampus or amygdala is sufficient to disrupt fear expression after relapse, while optogenetic stimulation of these same ensembles after extinction is insufficient to artificially mimic fear relapse. These results suggest that fear relapse triggers a partial re-emergence of the original fear memory representation, providing new insight into the neural substrates of fear relapse.
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影响因子：
2.5
作者：
Goode, Travis D.;Maren, Stephen
通讯作者：
Maren, Stephen
影响因子：
64.8
作者：
Hainmueller T;Bartos M
通讯作者：
Bartos M
恐惧灭绝作为转化神经科学的模型：十年的进步。
影响因子：
24.8
作者：
Milad MR;Quirk GJ
通讯作者：
Quirk GJ
DOI：
10.1016/j.cub.2018.03.051
发表时间：
2018-05-21
期刊：
Current biology : CB
影响因子：
--
作者：
Mau W;Sullivan DW;Kinsky NR;Hasselmo ME;Howard MW;Eichenbaum H
通讯作者：
Eichenbaum H
影响因子：
15.9
作者：
Clem RL;Schiller D
通讯作者：
Schiller D