Impact of childhood trauma on sensory gating in patients with first-episode schizophrenia.
Impact of childhood trauma on sensory gating in patients with first-episode schizophrenia.
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童年创伤对首发精神分裂症患者感觉门控的影响
DOI：
10.1186/s12888-018-1807-7
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发表时间：
2018-08-16
期刊：
影响因子：
4.4
通讯作者：
Wang CY
中科院分区：
文献类型：
--
作者：
Li XB;Bo QJ;Tian Q;Yang NB;Mao Z;Zheng W;Wen YJ;Wang CY
背景已发现儿童创伤（CT）会导致精神分裂症的发病，而听觉感觉门控缺陷是精神分裂症的主要内表型。然而，首发精神分裂症中 CT 与感觉门控之间的关联仍然难以捉摸。方法使用儿童创伤问卷简表 (CTQ-SF) 评估 CT，使用阳性和阴性症状量表 (PANSS) 评估症状严重程度，对 56 名患者和 49 名年龄和性别匹配的健康对照进行评估。使用改进的范式、感知空间分离诱导的前脉冲抑制（PSS-PPI）和感知空间共置PPI（PSC-PPI或经典PPI）测试感觉门控。结果与健康对照相比，患者的性虐待得分显着较高（t= 2.729，p< 0.05），较低的PSS-PPI，% （ISI = 120 ms 和 ISI = 60 ms）（t= − 3.089，− 4.196，p< 0.05）。单变量分析显示 CT、PPI 范式和症状之间不存在显着相关性。然而，多元线性回归分析显示CTQ-SF总和与PSS PPI呈负相关（ISI = 120 ms）（p= 0.018）。 结论本研究说明CT对首发精神分裂症患者感觉门控的影响，因此我们得出结论，CT可能通过其对感觉门控的影响而成为精神分裂症发生的危险因素。
BackgroundChildhood trauma (CT) has been found to contribute to the onset of schizophrenia and auditory sensory gating deficit is a leading endophenotype for schizophrenia. However, the association between the CT and sensory gating in first-episode schizophrenia remains elusive.MethodsFifty-six patients and 49 age and sex-matched healthy controls were assessed using the Childhood Trauma Questionnaire-Short Form (CTQ-SF) for CT and Positive and Negative Syndrome Scale (PANSS) for symptoms severity. Sensory gating was tested using the modified paradigm, perceived spatial separation-induced prepulse inhibition (PSS-PPI), and the perceived spatial co-location PPI (PSC-PPI or classical PPI).ResultsComparing with healthy controls, the patients had significantly higher score on sexual abuse (t= 2.729,p< 0.05), lower PSS- PPI, % (ISI = 120 ms and ISI = 60 ms) (t= − 3.089, − 4.196,p< 0.05). Univariate analysis revealed the absence of a significant correlation among CT, PPI paradigms and symptoms. However, multiple linear regression analyses demonstrated the CTQ-SF total was negatively associated with PSS PPI (ISI = 120 ms) (p= 0.018).ConclusionThe current study illustrates that the impact of CT on sensory gating in patients with first-episode schizophrenia, and thus we conclude that CT may be a risk factor to the occurrence of schizophrenia through its impact on sensory gating.
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DOI：
10.1016/s0140-6736(15)01121-6
发表时间：
2016-07-02
期刊：
Lancet (London, England)
影响因子：
--
作者：
Owen MJ;Sawa A;Mortensen PB
通讯作者：
Mortensen PB
影响因子：
3.6
作者：
Kumari, Veena;Fannon, Dominic;Geyer, Mark A.;Premkumar, Preethi;Antonova, Elena;Simmons, Andrew;Kuipers, Elizabeth
通讯作者：
Kuipers, Elizabeth
影响因子：
11.3
作者：
Duncan, E;Szilagyi, S;Rotrosen, J
通讯作者：
Rotrosen, J
影响因子：
10.6
作者：
GEYER, MA;WILKINSON, LS;ROBBINS, TW
通讯作者：
ROBBINS, TW
影响因子：
64.8
作者：
van Os, Jim;Kenis, Gunter;Rutten, Bart P. F.
通讯作者：
Rutten, Bart P. F.